Identification of neutralizing epitopes within structural domain III of the West Nile virus envelope protein

被引：222

作者：

Beasley, DWC

Barrett, ADT

机构：

[1] Univ Texas, Med Branch, Dept Pathol, Galveston, TX 77555 USA

[2] WHO, Collaborating Ctr Trop Dis, Sealy Ctr Vaccine Dev, Galveston, TX 77555 USA

来源：

JOURNAL OF VIROLOGY | 2002年 / 76卷 / 24期

关键词：

D O I：

10.1128/JVI.76.24.13097-13100.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Using a panel of neutralizing monoclonal antibodies, we have mapped epitopes in domain III of the envelope protein of the New York strain of West Nile virus. The ability of monoclonal antibodies that recognize these epitopes to neutralize virus appeared to differ between lineage I and II West Nile virus strains, and epitopes were located on the upper surface of domain III at residues E307, E330, and E332.

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页码：13097 / 13100

页数：4

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