Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats

被引：35

作者：

Isa, Katsunori ^{[1
]}

Garcia-Espinosa, Maria Antonia ^{[1
]}

Arnold, Amy C. ^{[1
]}

Pirro, Nancy T. ^{[1
]}

Tommasi, Ellen N. ^{[1
]}

Ganten, Detlev ^{[1
]}

Chappell, Mark C. ^{[1
]}

Ferrario, Carlos M. ^{[1
]}

Diz, Debra I. ^{[1
]}

机构：

[1] Wake Forest Univ Hlth Sci, Hypertens & Vasc Res Ctr, Winston Salem, NC USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2009年 / 297卷 / 01期

基金：

美国国家卫生研究院;

关键词：

hypertension; transgenic rats; renin-angiotensin system; brain; sympathetic nerve; antibody; PEPTIDE; SYSTEM; PROANGIOTENSIN-12; MECHANISMS; PATHWAYS; MEDULLA; KIDNEY; HEART;

D O I：

10.1152/ajpregu.90588.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, Ganten D, Chappell MC, Ferrario CM, Diz DI. Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2) 27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol 297: R111-R115, 2009. First published April 29, 2009; doi:10.1152/ajpregu.90588.2008.-Angiotensin-(1-12) [ANG(1-12)] is a newly identified peptide detected in a variety of rat tissues, including the brain. To determine whether brain ANG-(1-12) participates in blood pressure regulation, we treated male adult (mRen2) 27 hypertensive rats (24-28 wk of age) with Anti-ANG-(1-12) IgG or Preimmune IgG via an intracerebroventricular cannula for 14 days. Immunoneutralization of brain ANG-(1-12) lowered systolic blood pressure (-43 +/- 8 mmHg on day 3 and -26 +/- 7 mmHg on day 10 from baseline, P < 0.05). Water intake was lower on intracereroventricular day 6 in the Anti-ANG-(1-12) IgG group, accompanied by higher plasma osmolality on day 13, but there were no differences in urine volume, food intake, or body weight during the 2-wk treatment. In Preimmune IgG-treated animals, there were no significant changes in these variables over the 2-wk period. The antihypertensive effects produced by endogenous neutralization of brain ANG-(1-12) suggest that ANG-(1-12) is functionally active in brain pathways regulating blood pressure.

引用

页码：R111 / R115

页数：5

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