Chemical modification of a viral cage for multivalent presentation

被引：142

作者：

Gillitzer, E ^{[1
]}

Willits, D ^{[1
]}

Young, M ^{[1
]}

Douglas, T ^{[1
]}

机构：

[1] Montana State Univ, Bozeman, MT 59715 USA

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 20期

关键词：

D O I：

10.1039/b207853h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we present generalized methods for chemically modifying the surface of a viral protein cage; this exploits the chemistry of native and engineered surface exposed functional groups for multivalent presentation of ligands.

引用

页码：2390 / 2391

页数：2

共 11 条

[1] Host-guest encapsulation of materials by assembled virus protein cages [J].

Douglas, T ;

Young, M .

NATURE, 1998, 393 (6681) :152-155

[2]

Douglas T, 2002, ADV MATER, V14, P415, DOI 10.1002/1521-4095(20020318)14:6<415::AID-ADMA415>3.0.CO

[3]

2-W

[4]

Douglas T, 1999, ADV MATER, V11, P679, DOI 10.1002/(SICI)1521-4095(199906)11:8<679::AID-ADMA679>3.0.CO

[5]

2-J

[6]

Hermanson G. T, 1996, BIOCONJUGATE TECHNIQ, P169

[7] Virus Particle Explorer (VIPER), a Website for virus capsid structures and their computational analyses [J].

Reddy, VS ;

Natarajan, P ;

Okerberg, B ;

Li, K ;

Damodaran, KV ;

Morton, RT ;

Brooks, C ;

Johnson, JE .

JOURNAL OF VIROLOGY, 2001, 75 (24) :11943-11947

[8] STRUCTURES OF THE NATIVE AND SWOLLEN FORMS OF COWPEA CHLOROTIC MOTTLE VIRUS DETERMINED BY X-RAY CRYSTALLOGRAPHY AND CRYOELECTRON MICROSCOPY [J].

SPEIR, JA ;

MUNSHI, S ;

WANG, GJ ;

BAKER, TS ;

JOHNSON, JE .

STRUCTURE, 1995, 3 (01) :63-78

[9]

Wang Q, 2002, ANGEW CHEM INT EDIT, V41, P459

[10] Natural supramolecular building blocks: Wild-type cowpea mosaic virus [J].

Wang, Q ;

Kaltgrad, E ;

Lin, TW ;

Johnson, JE ;

Finn, MG .

CHEMISTRY & BIOLOGY, 2002, 9 (07) :805-811

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