Characteristics of receptor- and transducer-coupled activation of the intracellular signalling in sensory neuron revealed by atomic force microscopy

被引：3

作者：

Khalisov, M. M. ^{[1
,2
]}

Penniyaynen, V. A. ^{[1
]}

Esikova, N. A. ^{[3
]}

Ankudinov, A. V. ^{[2
,4
]}

Krylov, B. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Pavlov Inst Physiol, St Petersburg 199034, Russia

[2] St Petersburg Natl Res Univ Informat Technol Mech, St Petersburg ITMO Univ, St Petersburg 197101, Russia

[3] Russian Acad Sci, Inst Analyt Instrumentat, St Petersburg 198095, Russia

[4] Russian Acad Sci, Ioffe Phys Tech Inst, St Petersburg 194021, Russia

来源：

TECHNICAL PHYSICS LETTERS | 2017年 / 43卷 / 01期

基金：

俄罗斯科学基金会;

关键词：

SLOW SODIUM-CHANNELS; RED-BLOOD-CELLS; SRC-KINASE; ATPASE; MODULATION; OUABAIN;

D O I：

10.1134/S1063785017010072

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

The mechanical properties of sensory neurons upon activation of intracellular cascade processes by comenic acid binding to a membrane opioid-like receptor (receptor-coupled), as well as a very low (endogenous) concentration of ouabain (transducer-coupled), have been investigated. Using atomic force microscopy, it is established that exposure to ouabain, in contrast to the impact of comenic acid, leads to a hardening of the neuron soma. This suggests that the receptor-coupled signal transmission to the cell genome is carried out through mechanisms that are different from the transducer-coupled signal pathways.

引用

页码：85 / 87

页数：3

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