Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune astrocytopathic channelopathy, characterized by the presence of pathogenic antibodies to aquaporin-4 (AQP-4) water channels. Several viral infections including HIV, influenza virus, varicella zoster virus, and Epstein Barr virus, among others, have been alleged to trigger NMOSD in both immunocompetent and immunocompromised individuals. Neurological manifestations of coronavirus infectious disease of 2019 (COVID-19) have been ever evolving and the spectrum of neuraxial involvement is broadening. Albeit it may affect any area of the neural axis, the involvement of the spinal cord is rare compared to that of the brain and of the peripheral nervous system. Cases with acute longitudinally extensive transverse myelitis (LETM) have been recently reported in SARS-CoV-2 infection but did not fulfill the international consensus diagnostic criteria for NMOSD. AQP-4-antibody-seropositive NMOSD following SARS-CoV-2 infection had not yet been reported. We herein report a novel case of a previously healthy man who presented with a clinical picture of bouts of vomiting and hiccoughs (area postrema syndrome), which rapidly evolved to acute LETM, all following SARS-CoV-2 infection. He was finally diagnosed to be a case of seropositive NMOSD which presented as area postrema syndrome. The response to immunomodulatory drugs was excellent.
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AlKetbi Reem, 2020, Radiol Case Rep, V15, P1591, DOI 10.1016/j.radcr.2020.06.001
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Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Ruscitti, Piero
Navarini, Luca
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Univ Campus Biomed Roma, Unit Allergol Clin Immunol & Rheumatol, Rome, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Navarini, Luca
Del Puente, Antonio
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Univ Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Del Puente, Antonio
Giacomelli, Roberto
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Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Chow, Chian Chiang Nicholas
Magnussen, John
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Magnussen, John
Ip, Jerome
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Sydney Adventist Hosp Ltd, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Ip, Jerome
Su, Yuen
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
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Univ Fed Sao Paulo, Escola Paulista Med, UNIFESP, Disciplina Neurociencia, Sao Paulo, BrazilKrankenanstalt Rudolfstiftung Wien, Messerli Inst, Vienna, Austria
Scorza, Fulvio A.
Ghosh, Ritwik
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Burdwan Med Coll & Hosp, Dept Gen Med, Burdwan, W Bengal, IndiaKrankenanstalt Rudolfstiftung Wien, Messerli Inst, Vienna, Austria
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Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Ruscitti, Piero
Navarini, Luca
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Univ Campus Biomed Roma, Unit Allergol Clin Immunol & Rheumatol, Rome, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Navarini, Luca
Del Puente, Antonio
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Univ Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
Del Puente, Antonio
Giacomelli, Roberto
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Univ Aquila, Dept Biotechnol & Appl Clin Sci, Rheumatol Unit, Laquila, ItalyUniv Naples Federico II, Dept Clin Med & Surg, Rheumatol Res Unit, Via S Pansini 5, I-80131 Naples, Italy
机构:
Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Chow, Chian Chiang Nicholas
Magnussen, John
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h-index: 0
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Magnussen, John
Ip, Jerome
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Sydney Adventist Hosp Ltd, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
Ip, Jerome
Su, Yuen
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Hornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, AustraliaHornsby Ku Ring Gai Hosp, Emergency Dept, Sydney, NSW, Australia
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Univ Fed Sao Paulo, Escola Paulista Med, UNIFESP, Disciplina Neurociencia, Sao Paulo, BrazilKrankenanstalt Rudolfstiftung Wien, Messerli Inst, Vienna, Austria
Scorza, Fulvio A.
Ghosh, Ritwik
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Burdwan Med Coll & Hosp, Dept Gen Med, Burdwan, W Bengal, IndiaKrankenanstalt Rudolfstiftung Wien, Messerli Inst, Vienna, Austria