New rearranged limonoids from Walsura cochinchinensis

被引：17

作者：

Han, Mei-Ling ^{[1
]}

Shen, Yu ^{[1
]}

Leng, Ying ^{[1
]}

Zhang, Hua ^{[1
]}

Yue, Jian-Min ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 37期

关键词：

PINNATA HASSK; INHIBITORS; MELIACEAE; ROBUSTA; BARK;

D O I：

10.1039/c4ra00708e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Sixteen new limonoids, walsucochinoids C-R (1-16) incorporating a rearranged carbon skeleton, were isolated from the twigs and leaves of Walsura cochinchinensis. Their structures were established by detailed interpretation of spectroscopic data with those of 1 and 10 being secured by single-crystal X-ray diffraction experiments. Bioassays revealed that walsucochinoids D (2) and E (3) were mild mouse and human 11 beta-HSD1 inhibitors with IC50 values of 13.4 +/- 1.7 and 8.25 +/- 0.69 mu M, respectively.

引用

页码：19150 / 19158

页数：9

共 11 条

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