LiCl-Mediated Preparation of Functionalized Benzylic Indium(III) Halides and Highly Chemoselective Palladium-Catalyzed Cross-Coupling in a Protic Cosolvent

被引：78
作者：
Chen, Yi-Hung [1 ]
Sun, Mai [1 ]
Knochel, Paul [1 ]
机构：
[1] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 12期
基金：
欧洲研究理事会;
关键词：
biaryls; cross-coupling; organoindium reagents; palladium; REAGENTS; ARYL; ORGANOMETALLICS; COMPLEXES; LIGANDS; ACCESS; ALLYL;
D O I：
10.1002/anie.200805588
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Sensitive functional groups such as COR, CHO, or CH2OH can be present in benzylic indium reagents prepared by the direct insertion of indium in the presence of LiCl. These reagents undergo palladium-catalyzed cross-coupling reactions in the presence of a protic cosolvent after activation with iPrMgCl·LiCl (see scheme). Remarkable chemoselectivities are achieved by using various electrophiles containing NH or OH groups. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：2236 / 2239
页数：4
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