5-HT modulation of identified segmental premotor interneurons in the lamprey spinal cord

被引：20

作者：

Biro, Zoltan ^{[1
]}

Hill, Russell H. ^{[1
]}

Grillner, Sten ^{[1
]}

机构：

[1] Karolinska Inst, Dept Neurosci, Nobel Inst Neurophysiol, SE-17177 Stockholm, Sweden

来源：

JOURNAL OF NEUROPHYSIOLOGY | 2006年 / 96卷 / 02期

关键词：

D O I：

10.1152/jn.00309.2006

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ipsilaterally projecting spinal excitatory interneurons (EINs) generate the hemisegmental rhythmic locomotor activity in lamprey, while the commissural interneurons ensure proper left-right alternation. 5-HT is a potent modulator of the locomotor rhythm and is endogenously released from the spinal cord during fictive locomotion. The effect of 5-HT was investigated for three segmental premotor interneuron types: EINs, commissural excitatory and commissural inhibitory interneurons. All three types of interneurons produced chemical postsynaptic potentials in motoneurons, but only those from EINs had an electrical component. The effect of 5-HT was studied on the slow afterhyperpolarization, involved in spike frequency regulation, and on the segmental synaptic transmission to motoneurons. 5-HT induced a reduction in the slow afterhyperpolarization and a depression of synaptic transmission in all three types of segmental interneurons. Thus 5-HT is a very potent modulator of membrane properties and synaptic transmission of last-order segmental premotor interneurons. Such modulation of locomotor network interneurons can partially account for the observed effects of 5-HT on the swimming pattern in lamprey.

引用

页码：931 / 935

页数：5

共 24 条

[1] A NEW CLASS OF SMALL INHIBITORY INTERNEURONES IN THE LAMPREY SPINAL-CORD [J].

BUCHANAN, JT ;

GRILLNER, S .

BRAIN RESEARCH, 1988, 438 (1-2) :404-407

[2] IDENTIFICATION OF INTERNEURONS WITH CONTRALATERAL, CAUDAL AXONS IN THE LAMPREY SPINAL-CORD - SYNAPTIC-INTERACTIONS AND MORPHOLOGY [J].

BUCHANAN, JT .

JOURNAL OF NEUROPHYSIOLOGY, 1982, 47 (05) :961-975

[3] NEWLY IDENTIFIED GLUTAMATE INTERNEURONS AND THEIR ROLE IN LOCOMOTION IN THE LAMPREY SPINAL-CORD [J].

BUCHANAN, JT ;

GRILLNER, S .

SCIENCE, 1987, 236 (4799) :312-314

[4] Mechanisms of rhythm generation in a spinal locomotor network deprived of crossed connections: The lamprey hemicord [J].

Cangiano, L ;

Grillner, S .

JOURNAL OF NEUROSCIENCE, 2005, 25 (04) :923-935

[5] Fast and slow locomotor burst generation in the hemispinal cord of the lamprey [J].

Cangiano, L ;

Grillner, S .

JOURNAL OF NEUROPHYSIOLOGY, 2003, 89 (06) :2931-2942

[6] Role of apamin-sensitive KCa channels for reticulospinal synaptic transmission to motoneuron and for the afterhyperpolarization [J].

Cangiano, L ;

Wallén, P ;

Grillner, S .

JOURNAL OF NEUROPHYSIOLOGY, 2002, 88 (01) :289-299

[7]

CHRISTENSON J, 1991, ADV NEUROSC, V1, P159

[8] INCREASE IN ENDOGENOUS 5-HYDROXYTRYPTAMINE LEVELS MODULATES THE CENTRAL NETWORK UNDERLYING LOCOMOTION IN THE LAMPREY SPINAL-CORD [J].

CHRISTENSON, J ;

FRANCK, J ;

GRILLNER, S .

NEUROSCIENCE LETTERS, 1989, 100 (1-3) :188-192

[9] STRYCHNINE ELIMINATES ALTERNATING MOTOR OUTPUT DURING FICTIVE LOCOMOTION IN THE LAMPREY [J].

COHEN, AH ;

HARRISWARRICK, RM .

BRAIN RESEARCH, 1984, 293 (01) :164-167

[10] CALCIUM-DEPENDENT POTASSIUM CHANNELS PLAY A CRITICAL ROLE FOR BURST TERMINATION IN THE LOCOMOTOR NETWORK IN LAMPREY [J].

ELMANIRA, A ;

TEGNER, J ;

GRILLNER, S .

JOURNAL OF NEUROPHYSIOLOGY, 1994, 72 (04) :1852-1861

← 1 2 3 →