Beta-blockers for hypertension: Are they going out of style?

被引:17
作者
Che, Qi [1 ]
Schreiber, Martin J., Jr. [1 ]
Rafey, Mohammed A. [1 ]
机构
[1] Cleveland Clin, Glickman Urol & Kidney Inst, Dept Hypertens & Nephrol, Cleveland, OH 44195 USA
关键词
RANDOMIZED-TRIAL; BLOOD-PRESSURE; CARDIOVASCULAR MORBIDITY; ELDERLY-PATIENTS; HEART-FAILURE; MYOCARDIAL-INFARCTION; SWEDISH TRIAL; OLD PATIENTS; MORTALITY; NEBIVOLOL;
D O I
10.3949/ccjm.76a.09030
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although beta-blockers lower blood pressure in most patients, the outcomes of clinical hypertension trials of these drugs have been disappointing, and the value of beta-blockers in treating hypertensive patients who do not have compelling indications for them has been questioned. Until these drugs are proved beneficial, they should be used as antihypertensive therapy only in patients with compelling cardiac indications for them or as add-on agents in those with uncontrolled or resistant hypertension.
引用
收藏
页码:533 / 542
页数:10
相关论文
共 66 条
[21]   Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA):: a multicentre randomised controlled trial [J].
Dahlöf, B ;
Sever, PS ;
Poulter, NR ;
Wedel, H ;
Beevers, DG ;
Caulfield, M ;
Collins, R ;
Kjeldsen, SE ;
Kristinsson, A ;
McInnes, GT ;
Mehlsen, J ;
Nieminen, M ;
O'Brien, E ;
Östergren, J .
LANCET, 2005, 366 (9489) :895-906
[22]   NEUROPSYCHOLOGICAL SIDE-EFFECTS OF BETA-BLOCKERS [J].
DIMSDALE, JE ;
NEWTON, RP ;
JOIST, T .
ARCHIVES OF INTERNAL MEDICINE, 1989, 149 (03) :514-525
[23]   ATENOLOL IN SECONDARY PREVENTION AFTER STROKE [J].
ERIKSSON, S ;
OLOFSSON, BO ;
WESTER, PO .
CEREBROVASCULAR DISEASES, 1995, 5 (01) :21-25
[24]   FASTTRACK Randomized trial to determine the effect of nebivolol on mortality and cardiovascular hospital admission in elderly patients with heart failure (SENIORS) [J].
Flather, MD ;
Shibata, MC ;
Coats, AJS ;
Van Veldhuisen, DJ ;
Parkhomenko, A ;
Borbola, J ;
Cohen-Solal, A ;
Dumitrascu, D ;
Ferrari, R ;
Lechat, P ;
Soler-Soler, J ;
Tavazzi, L ;
Spinarova, L ;
Toman, J ;
Böhm, M ;
Anker, SD ;
Thompson, SG ;
Poole-Wilson, PA .
EUROPEAN HEART JOURNAL, 2005, 26 (03) :215-225
[25]  
Franklin SS, 1997, CIRCULATION, V96, P308
[26]   CLINICAL PHARMACOLOGY OF THE NEW BETA-ADRENERGIC BLOCKING-DRUGS .2. PHYSIOLOGIC AND METABOLIC EFFECTS [J].
FRISHMAN, W ;
SILVERMAN, R .
AMERICAN HEART JOURNAL, 1979, 97 (06) :797-807
[27]   PLASMA-RENIN ACTIVITY SUPPRESSION - DURATION AFTER WITHDRAWAL FROM BETA-ADRENERGIC-BLOCKADE [J].
GARRETT, BN ;
KAPLAN, NM .
ARCHIVES OF INTERNAL MEDICINE, 1980, 140 (10) :1316-1318
[28]   The cellular mechanisms involved in the vasodilator effect of nebivolol on the renal artery [J].
Georgescu, A ;
Pluteanu, F ;
Flonta, ML ;
Badila, E ;
Dorobantu, M ;
Popov, D .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2005, 508 (1-3) :159-166
[29]   Effects of perindopril and carvedilol on endothelium-dependent vascular functions in patients with diabetes and hypertension [J].
Giugliano, D ;
Marfella, R ;
Acampora, R ;
Giunta, R ;
Coppola, L ;
D'Onofrio, F .
DIABETES CARE, 1998, 21 (04) :631-636
[30]  
GREENBERG G, 1985, BMJ-BRIT MED J, V291, P97