Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth

被引：225
作者：
Kottis, V
Thibault, P
Mikol, D
Xiao, ZC
Zhang, R
Dergham, P
Braun, PE [1 ]
机构：
[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 176, Canada
[2] CNR, Inst Biol Sci, Ottawa, ON, Canada
[3] Univ Michigan, Dept Neurol, Ann Arbor, MI USA
[4] Univ Montreal, Dept Pathol, Montreal, PQ H3C 3J7, Canada
来源：
JOURNAL OF NEUROCHEMISTRY | 2002年 / 82卷 / 06期
关键词：
arretin; myelin inhibitors; nerve regeneration; neurite outgrowth; OMgp;
D O I：
10.1046/j.1471-4159.2002.01146.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A protein fraction purified from bovine brain myelin, previously called arretin because of its ability to inhibit neurite outgrowth, has been identified as consisting predominantly of oligodendrocyte-myelin glycoprotein (OMgp). We show that it is a potent inhibitor of neurite outgrowth from rat cerebellar granule and hippocampal cells; from dorsal root ganglion explants in which growth cone collapse was observed; from rat retinal ganglion neurons; and from NG108 and PC12 cells. OMgp purified by a different procedure from both mouse and human myelin behaves identically in all bioassays tested.
引用
收藏
页码：1566 / 1569
页数：4
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