Short-term Outcome of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Preliminary Analysis of a Multicentre Study

被引：1

作者：

Macri, Antonio ^{[1
]}

Arcoraci, Vincenzo ^{[2
]}

Belgrano, Valerio ^{[3
]}

Caldana, Marina ^{[4
]}

Cioppa, Tommaso ^{[5
]}

Costantini, Barbara ^{[6
]}

Cucinotta, Eugenio ^{[1
]}

De Cian, Franco ^{[3
]}

De Iaco, Pierandrea ^{[7
]}

De Manzoni, Giovanni ^{[4
]}

Di Giorgio, Angelo ^{[8
]}

Fleres, Francesco ^{[1
]}

Muffatti, Francesca ^{[9
]}

Orsenigo, Elena ^{[9
]}

Pinna, Antonio Daniele ^{[10
]}

Roviello, Franco ^{[5
]}

Sammartino, Paolo ^{[8
]}

Scambia, Giovanni ^{[6
]}

Saladino, Edoardo ^{[1
]}

机构：

[1] Univ Messina, Dept Human Pathol, I-98125 Messina, Italy

[2] Univ Messina, Dept Clin & Expt Med, I-98125 Messina, Italy

[3] Univ Genoa, Dept Surg, Genoa, Italy

[4] Univ Verona, Dept Gen Surg 1, I-37100 Verona, Italy

[5] Univ Siena, Dept Med Surg & Neurosci, I-53100 Siena, Italy

[6] Univ Cattolica Sacro Cuore, Dept Obstet & Gynaecol, I-00168 Rome, Italy

[7] St Orsola Marcello Malpighi Hosp, Gynecol Oncol Unit, Bologna, Italy

[8] Univ Roma La Sapienza, Dept Surg Pietro Valdoni, I-00185 Rome, Italy

[9] Ist Sci San Raffaele, Dept Surg, I-20132 Milan, Italy

[10] St Orsola Marcello Malpighi Hosp, Dept Med & Surg Sci, Bologna, Italy

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 10期

关键词：

Cytoreductive surgery; HIPEC hyperthermia; morbidity; mortality; PERITONEAL CARCINOMATOSIS; PSEUDOMYXOMA PERITONEI; LEARNING-CURVE; MORBIDITY; MORTALITY; COMPLICATIONS; CLASSIFICATION; SURVIVAL; TOXICITY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To assess the incidence of morbidity and mortality of Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy. Patients and Methods: A retrospective multicentric study was performed. Six hundred and eighty-three patients were recorded. Predictors of morbidity and mortality were evaluated with univariate and multivariate analysis. Results: In univariate analysis, older age, Eastern Cooperative Oncology Group score, a greater value of Peritoneal Cancer Index (PCI) and sub-optimal cytoreduction were correlated with higher mortality, while older age, presence of ascites, ovarian origin of carcinomatosis, closed technique, a greater value of PCI, longer operative time and sub-optimal cytoreduction were predictors of higher morbidity. In multivariate analysis, older age and a greater value of PCI were correlated with higher mortality; older age, ovarian origin of tumor, presence of ascites, closed technique and longer operative time were predictors of higher morbidity. Conclusion: Careful patient selection has to be performed to improve clinical outcomes.

引用

页码：5689 / 5693

页数：5

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