Biomimetic Mesoporous Silica Nanoparticles for Enhanced Blood Circulation and Cancer Therapy

被引：39

作者：

Peng, Haibao ^{[1
]}

Xu, Zhuoyuan ^{[2
]}

Wang, Yongcheng ^{[3
]}

Feng, Nianping ^{[1
]}

Yang, Wuli ^{[4
]}

Tang, Jing ^{[5
]}

机构：

[1] Shanghai Univ Tradit Chinese Med, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China

[2] Rice Univ, Dept Chem & Biomol Engn, Houston, TX 77005 USA

[3] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

[4] Fudan Univ, Dept Macromol Sci, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China

[5] Stanford Univ, Dept Mat Sci & Engn, Stanford, CA 94305 USA

来源：

ACS APPLIED BIO MATERIALS | 2020年 / 3卷 / 11期

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

red blood cell; mesoporous silica nanoparticles; surface functionalization; long circulation; photothermal therapy; DRUG-DELIVERY; ERYTHROCYTE-MEMBRANE; NANOCARRIERS; SUSPENSIONS;

D O I：

10.1021/acsabm.0c01014

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The biomimetic cell membrane camouflaged approach provides numerous opportunities in designing therapeutic platforms for various biomedical applications. It is necessary to understand the engineering of physicochemical properties on materials' surfaces for target biological functions to develop the next-generation anticancer nanomedicines. Herein, we envelope mesoporous silica nanoparticles (MSNs) with red blood cell (RBC) membrane ghosts to obtain MSN@RBC, which possesses significantly stronger physiological stability and longer circulation time than bare MSNs. The surface functionalization of the core material is a critical design parameter for RBC membrane coating efficiency. Therefore, various surface functionalization (-COOH, -SH, -NH2) modifications were performed on MSNs. Compared with other groups, MSN-COOH possessed a better RBC membrane coating efficiency. Then, MSN-COOH of different particle sizes were coated by RBC-derived vesicle membranes. The results indicated that smaller types were able to last longer in blood circulation and accumulate more in target sites than the larger ones. Overall, MSN-ICG@RBC with surface functionalization of -COOH and optimized particle size of 60 nm led to efficient imaging-guided photothermal cancer treatment and could be potentially appealing to actual clinical applications in the future.

引用

页码：7849 / 7857

页数：9

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