Improving CAR T cell immunotherapy-mediated remissions for pediatric leukemia

被引：6

作者：

Barrett, David M. ^{[1
]}

机构：

[1] Childrens Hosp Philadelphia, Ctr Childhood Canc Res, Cell Therapy Program, Philadelphia, PA 19104 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2019年 / 129卷 / 05期

关键词：

ACUTE LYMPHOBLASTIC-LEUKEMIA; CHILDREN;

D O I：

10.1172/JCI128743

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Chimeric antigen receptor (CAR) T cells are an effective therapy for relapsed or refractory pediatric B cell leukemia. Analysis of the starting material, the T cells collected from the patient prior to CAR manufacture, reveals possible biomarkers of cells destined to perform poorly in patients. Long-term follow-up shows that long periods of B cell aplasia, a marker of in vivo CAR activity, are associated with longer remission but also a higher chance of antigen-negative relapse. The role of transplantation as consolidative therapy is unclear in this nonrandomized data, but clearly warrants further study.

引用

页码：1842 / 1844

页数：3

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