Inhibition of NF-κB and metalloproteinase-9 expression and secretion by parthenolide derivatives

被引：27

作者：

Dell'Agli, Mario ^{[1
]}

Galli, Germana V. ^{[1
]}

Bosisio, Enrica ^{[1
]}

D'Ambrosio, Michele ^{[2
]}

机构：

[1] Univ Milan, Dept Pharmacol Sci, I-20122 Milan, Italy

[2] Univ Trent, Chim Bioorgan Lab, I-38100 Trento, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 07期

关键词：

Metalloproteinase-9; Gene expression; Parthenolide; Sesquiterpenes; Parthenolide derivatives; NF-kappa B driven transcription; SESQUITERPENE LACTONES; MATRIX METALLOPROTEINASES; ACTIVATION; MATRIX-METALLOPROTEINASE-9; P65/NF-KAPPA-B; FEVERFEW; PATHWAY; ALPHA;

D O I：

10.1016/j.bmcl.2009.02.080

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Semisynthetic derivatives of parthenolide (1) were tested on NF-kappa B driven transcription and metalloproteinase-9 (MMP-9) expression and secretion. The four membered ring compounds 5 and 6, obtained by acidic treatment of 1, exhibited a higher activity with respect to 1 in all the biological assays. Then an increased ability of the 5 and 6 to inhibit NF-kappa B driven transcription may lead to a down-regulation of MMP-9 expression and secretion. This work provides new details about the structural requisites for NF-kappa B inhibition. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1858 / 1860

页数：3

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