Heparin-functionalized polymeric biomaterials in tissue engineering and drug delivery applications

被引：291
作者：
Liang, Yingkai [1 ]
Kiick, Kristi L. [1 ,2 ,3 ]
机构：
[1] Univ Delaware, Dept Mat Sci & Engn, Newark, DE 19716 USA
[2] Univ Delaware, Newark, DE 19716 USA
[3] Univ Delaware, Delaware Biotechnol Inst, Newark, DE 19711 USA
来源：
ACTA BIOMATERIALIA | 2014年 / 10卷 / 04期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Heparin; Hydrogels; Nanoparticles; Tissue engineering; Drug delivery; GROWTH-FACTOR DELIVERY; MOLECULAR-WEIGHT HEPARIN; MIMETIC PEPTIDE NANOFIBERS; GLYCOL) STAR COPOLYMER; CONTROLLED-RELEASE; IN-VIVO; BIOMEDICAL APPLICATIONS; MIMICKING POLYMER; PLURONIC NANOGELS; GLYCOSAMINOGLYCAN HYDROGELS;
D O I：
10.1016/j.actbio.2013.07.031
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Heparin plays an important role in many biological processes via its interaction with various proteins, and hydrogels and nanoparticles comprising heparin exhibit attractive properties, such as anticoagulant activity, growth factor binding, and antiangiogenic and apoptotic effects, making them great candidates for emerging applications. Accordingly, this review summarizes recent efforts in the preparation of heparin-based hydrogels and formation of nanoparticles, as well as the characterization of their properties and applications. The challenges and future perspectives for heparin-based materials are also discussed. Prospects are promising for heparin-containing polymeric biomaterials in diverse applications ranging from cell carriers for promoting cell differentiation to nanoparticle therapeutics for cancer treatment. (C) 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：1588 / 1600
页数：13
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