C5-Modified nucleosides exhibiting anticancer activity

被引：62

作者：

Lee, Yoon-Suk ^{[1
]}

Park, Sun Min ^{[1
]}

Kim, Hwan Mook ^{[2
]}

Park, Song-Kyu ^{[2
]}

Lee, Kiho ^{[2
]}

Lee, Chang Woo ^{[2
]}

Kim, Byeang Hyean ^{[1
]}

机构：

[1] Pohang Univ Sci & Technol, Dept Chem, BK Sch Mol Sci, Pohang 790784, South Korea

[2] Bioevaluat Ctr, KRIBB, Taejon 305806, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 16期

关键词：

Anticancer; Nucleoside; Triazole; Isoxazole; Cycloaddition; CANCER; IDENTIFICATION; CYTOTOXICITY; CLOFARABINE; ISOXAZOLE; ANALOGS; DESIGN; CELLS;

D O I：

10.1016/j.bmcl.2009.06.072

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We describe (i) a simple method for the synthesis of C5-modified nucleosides from 5-iodo-2'deoxyuridine and (ii) their activity against six types of human cancer cell lines (HCT15, MM231, NCI-H23, NUGC-3, PC-3, ACHN). We generated nitrile oxides in situ from oximes using a commercial bleaching agent; their cycloadditions with 5-ethynyl-2'-deoxyuridine yielded isoxazole derivatives possessing activity against the cancer cell lines. We synthesized several azides from benzylic bromides and their click reactions with 5-ethynyl-2'-deoxyuridine provided triazole derivatives. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4688 / 4691

页数：4

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