Translocation-Related Sarcomas

被引：53

作者：

Mertens, Fredrik ^{[7
]}

Antonescu, Cristina R. ^{[6
]}

Hohenberger, Peter ^{[5
]}

Ladanyi, Marc ^{[6
]}

Modena, Piergiorgio ^{[3
]}

D'Incalci, Maurizio ^{[4
]}

Casali, Paolo G.

Aglietta, Massimo ^{[2
]}

Alvegard, Thor ^{[1
]}

机构：

[1] Univ Lund Hosp, Dept Canc Epidemiol, S-22185 Lund, Sweden

[2] Univ Turin, IRCC, Osped Mauriziano, Candiolo, Italy

[3] Ist Nazl Tumori, Fdn IRCCS, Unit Mol Cytogenet, I-20133 Milan, Italy

[4] Mario Negri Inst Pharmacol Res, Dept Oncol, Milan, Italy

[5] Univ Hosp Mannheim, Dept Surg, Div Surg Oncol & Thorac Surg, Mannheim, Germany

[6] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[7] Univ Lund Hosp, Dept Clin Genet, S-22185 Lund, Sweden

来源：

SEMINARS IN ONCOLOGY | 2009年 / 36卷 / 04期

关键词：

CLEAR-CELL SARCOMA; GRADE FIBROMYXOID SARCOMA; MOLECULAR-GENETIC CHARACTERIZATION; FUSION TRANSCRIPT STRUCTURE; CHILDRENS ONCOLOGY GROUP; PHASE-II TRIAL; MYXOID LIPOSARCOMA; DERMATOFIBROSARCOMA PROTUBERANS; ALVEOLAR RHABDOMYOSARCOMA; MALIGNANT-MELANOMA;

D O I：

10.1053/j.seminoncol.2009.06.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sarcomas with chromosomal translocations represent only about one fourth of sarcoma diagnoses. However, like gastrointestinal stromal tumor (GIST), with its characteristic KIT or PDGFRA mutations, they are particularly interesting since they provide specific biological insights and mechanisms of action that may have an impact upon prognosis or therapy. These are mechanisms we are just beginning to exploit. In this section we will review the biology and clinical impact of translocation-associated sarcomas and review the clinical findings that have made a recent impact upon patients with these diverse diagnoses. © 2009.

引用

页码：312 / 323

页数：12

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