Felis catus gammaherpesvirus 1; a widely endemic potential pathogen of domestic cats

被引：39

作者：

Beatty, Julia A. ^{[1
,2
]}

Troyer, Ryan M. ^{[3
]}

Carver, Scott ^{[4
]}

Barrs, Vanessa R. ^{[1
,2
]}

Espinasse, Fanny ^{[1
,2
]}

Conradi, Oliver ^{[1
,2
]}

Stutzman-Rodriguez, Kathryn ^{[3
]}

Chan, Cathy C. ^{[5
]}

Tasker, Severine ^{[6
]}

Lappin, Michael R. ^{[7
]}

VandeWoude, Sue ^{[3
]}

机构：

[1] Univ Sydney, Fac Vet Sci, Valentine Charlton Cat Ctr, Sydney, NSW 2006, Australia

[2] Univ Sydney, Marie Bashir Inst Infect Dis & Biosecur, Sydney, NSW 2006, Australia

[3] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

[4] Univ Tasmania, Sch Biol Sci, Hobart, Tas 7001, Australia

[5] Anim Doctors Pte Ltd, Singapore, Singapore

[6] Univ Bristol, Sch Vet Sci, Bristol BS40 5DU, Avon, England

[7] Colorado State Univ, Dept Clin Sci, Ft Collins, CO 80522 USA

来源：

VIROLOGY | 2014年 / 460卷

基金：

美国国家科学基金会;

关键词：

Gammaherpesvirus; Feline; Molecular epidemiology; Copathogen; Transmission; IMMUNODEFICIENCY VIRUS-INFECTION; LEUKEMIA-VIRUS; EBV LOAD; BARTONELLA; BLOOD; PREVALENCE; MODEL; PCR; DNA; IDENTIFICATION;

D O I：

10.1016/j.virol.2014.05.007

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Felis catus gammaherpesvirus 1 (FcaGHV1), recently discovered in the USA, was detected in domestic cats in Australia (11.4%, 95% confidence interval 5.9-19.1, n=110) and Singapore (9.6%, 95% confidence interval 5.9-14.6, n=176) using qPCR. FcaGHV1 qPCR positive cats were 2.8 times more likely to be sick than healthy. Risk factors for FcaGHV1 detection included being male, increasing age and coinfection with pathogenic retroviruses, feline immunodeficiency virus (Fly) or feline leukaemia virus. FcaGHV1 DNA was detected in multiple tissues from infected cats with consistently high virus loads in the small intestine. FcaGHY1 viral load was significantly higher in Fly-infected cats compared with matched controls, mimicking increased Epstein-Barr virus loads in human immunodeficiency virus-infected humans. FcaGHV1 is endemic in distant geographic regions and is associated with being sick and with coinfections. Horizontal transmission of FcaGHY1 is supported, with biting being a plausible route. A pathogenic role for FcaGHV1 in domestic cats is supported. (C) 2014 Elsevier Inc. All rights reserved.

引用

页码：100 / 107

页数：8

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