Detection of Herpesvirus, Enterovirus, and Arbovirus Infection in Patients With Suspected Central Nervous System Viral Infection in the Western Brazilian Amazon

被引：51

作者：

Bastos, Michele S. ^{[1
,2
]}

Lessa, Natalia ^{[1
,3
]}

Naveca, Felipe G. ^{[4
]}

Monte, Rossicleia L. ^{[1
]}

Braga, Wornei S. ^{[1
]}

Figueiredo, Luiz Tadeu M. ^{[5
]}

Ramasawmy, Rajendranath ^{[1
,2
,6
]}

Mourao, Maria Paula G. ^{[1
,2
,6
]}

机构：

[1] Fundacao Med Trop Dr Heitor Vieira Dourado, Manaus, Amazonas, Brazil

[2] Univ Estado Amazonas, Manaus, Amazonas, Brazil

[3] Univ Fed Amazonas, Manaus, Amazonas, Brazil

[4] Fiocruz MS, Ctr Pesquisa Leonidas & Maria Deane, Manaus, Amazonas, Brazil

[5] Fac Med Ribeirao Preto, Sao Paulo, Brazil

[6] Univ Nilton Lins, Manaus, Amazonas, Brazil

来源：

JOURNAL OF MEDICAL VIROLOGY | 2014年 / 86卷 / 09期

关键词：

encephalitis; meningitis; arbovirus; enterovirus; herpesvirus; VARICELLA-ZOSTER-VIRUS; EPSTEIN-BARR-VIRUS; CEREBROSPINAL-FLUID; NESTED-PCR; NEUROLOGICAL MANIFESTATIONS; ASEPTIC-MENINGITIS; DENGUE INFECTION; SIMPLEX-VIRUS; ENCEPHALITIS; DIAGNOSIS;

D O I：

10.1002/jmv.23953

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Acute infections of the central nervous system (CNS) can be caused by various pathogens. In this study, the presence of herpesviruses (HHV), enteroviruses (EVs), and arboviruses were investigated in CSF samples from 165 patients with suspected CNS viral infection through polymerase chain reaction (PCR) and reverse transcriptase PCR. The genomes of one or more viral agents were detected in 29.7% (49/165) of the CSF samples. EVs were predominant (16/49; 32.6%) followed by Epstein-Barr virus (EBV) (22.4%), Varicella-Zoster virus (VZV) (20.4%), Cytomegalovirus (CMV) (18.4%), herpes simplex virus (HSV-1) (4.1%), (HSV-2) (4.1%), and the arboviruses (14.3%). Four of the arboviruses were of dengue virus (DENV) and three of oropouche virus (OROV). The detection of different viruses in the CNS of patients with meningitis or encephalitis highlight the importance of maintaining an active laboratory monitoring diagnostics with rapid methodology of high sensitivity in areas of viral hyperendemicity that may assist in clinical decisions and in the choice of antiviral therapy. (C) 2014 Wiley Periodicals, Inc.

引用

页码：1522 / 1527

页数：6

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