Method for the synthesis of N-alkyl-O-alkyl carbamates

被引：14

作者：

Vaillard, Victoria A. ^{[1
]}

Gonzalez, Marianela ^{[1
]}

Perotti, Jesica P. ^{[1
]}

Grau, Ricardo J. A. ^{[1
]}

Vaillard, Santiago E. ^{[1
]}

机构：

[1] UNL, CONICET, Ctr Cient Tecnol Santa Fe, Inst Desarrollo Tecnol Ind Quim INTEC, RA-3000 Santa Fe, Argentina

来源：

RSC ADVANCES | 2014年 / 4卷 / 25期

关键词：

SOLID-PHASE SYNTHESIS; CARBAMOYLIMIDAZOLIUM; PROTOCOL; REAGENTS; EFFICIENT; ALCOHOLS; AMIDES; UREAS; SALTS;

D O I：

10.1039/c4ra00373j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Primary and secondary carbamates were prepared from primary, secondary and neo-pentyl alcohols, and carbonyl-di-imidazole (CDI), using a new three step method. Non-acidic alcohols reacted with CDI affording carbamoyl-imidazoles with excellent yields (92-97%). The carbamoyl-imidazoles were then converted into the more reactive imidazolium salts, which upon reaction with primary and secondary amines afforded the corresponding carbamates in high isolated yields (66-99%).

引用

页码：13012 / 13017

页数：6

共 26 条

[1] ESTERS OF CARBAMIC ACID [J].