Hypertensive Disorders of Pregnancy

被引:55
|
作者
Shah, Silvi [1 ]
Gupta, Anu [2 ]
机构
[1] Univ Cincinnati, Div Nephrol, Kidney CARE Program, 231 Albert Sabin Way,MSB 6211, Cincinnati, OH 45267 USA
[2] Buffalo Med Grp, 2121 Main St 305, Buffalo, NY 14214 USA
关键词
Hypertension; Pregnancy; Preeclampsia; Treatment; ADVERSE PERINATAL OUTCOMES; FETAL-GROWTH RESTRICTION; ELEVATED LIVER-ENZYMES; RISK-FACTORS; GESTATIONAL HYPERTENSION; SOLUBLE ENDOGLIN; CARDIOVASCULAR RISK; SEVERE PREECLAMPSIA; ANGIOGENIC FACTORS; CONTROLLED-TRIAL;
D O I
10.1016/j.ccl.2019.04.008
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Hypertensive disorders of pregnancy are common and contribute inordinately to maternal and fetal morbidity and mortality. Although not completely understood, recent clinical trials have provided important insights into pathogenesis of pre-eclampsia. Preeclampsia is considered a systemic disease with generalized endothelial dysfunction and risk of future cardiovascular disease. This review revisits the definitions and classifications of hypertensive disorders of pregnancy; discusses updates on pathophysiology, prevention, and early prediction of pre-eclampsia; reviews current management guidelines; and discusses potential risks and benefits associated with treatment. Improvement in management and outcomes of women with hypertensive disorders of pregnancy seems in sight in the near future.
引用
收藏
页码:345 / +
页数:11
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