Genetic variants in the plasminogen activator inhibitor-1 gene are associated with an increased risk of radiation pneumonitis in lung cancer patients

被引：13

作者：

Liu, Bo ^{[1
]}

Tang, Yang ^{[1
]}

Yi, Minxiao ^{[1
]}

Liu, Qingxu ^{[1
]}

Xiong, Huihua ^{[1
]}

Hu, Guangyuan ^{[1
]}

Yuan, Xianglin ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Oncol, 1095,Jiefang Rd, Wuhan, Hunan, Peoples R China

来源：

CANCER MEDICINE | 2017年 / 6卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Lung cancer; PAI-1; Radiation pneumonitis; Radiotherapy; Single-nucleotide polymorphism; TGF-BETA; MYOCARDIAL-INFARCTION; PULMONARY-FIBROSIS; PLASMA PAI-1; POLYMORPHISM; EXPRESSION; PARAMETERS; TOXICITY; GENOTYPE; PATHWAY;

D O I：

10.1002/cam4.1011

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Plasminogen activator inhibitor-1 (PAI-1) plays a crucial role in the process of lung injury, although its association with radiation pneumonitis (RP) is unclear. We hypothesized that genetic variants in PAI-1 may influence the risk of RP. In this study, 169 lung cancer patients were genotyped for six single-nucleotide polymorphisms in PAI-1 using the Sequenom MassARRAY system. The risk of RP was evaluated by Cox proportional hazards analyses. The cumulative RP probabilities by genotype were assessed using Kaplan-Meier analyses. Univariate and multivariate analyses revealed that PAI-1: rs7242 GT/GG was correlated with an increased occurrence of grade >= 3 RP (crude hazard ratio = 3.331; 95% confidence interval, 1.168-9.497; P = 0.024). Our results indicated that PAI-1: rs7242 in the 3'-untranslated region of PAI-1 can be a predictor of grade >= 3 RP before radiotherapy.

引用

页码：681 / 688

页数：8

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