Supplemental Substances Derived from Foods as Adjunctive Therapeutic Agents for Treatment of Neurodegenerative Diseases and Disorders

被引:44
作者
Bigford, Gregory E. [1 ]
Del Rossi, Gianluca [2 ]
机构
[1] Univ Miami, Miller Sch Med, Miami Project Cure Paralysis, Miami, FL 33136 USA
[2] Univ S Florida, Coll Med, Dept Orthoped & Sports Med, Tampa, FL 33620 USA
关键词
ACETYL-L-CARNITINE; TRAUMATIC BRAIN-INJURY; FATTY-ACID-COMPOSITION; DIETARY DOCOSAHEXAENOIC ACID; INDUCED COGNITIVE IMPAIRMENT; LAVANDULAEFOLIA ESSENTIAL OIL; REDUCES OXIDATIVE DAMAGE; ALPHA-LIPOIC ACID; INFUSED RAT MODEL; ALZHEIMERS-DISEASE;
D O I
10.3945/an.113.005264
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Neurodegenerative disorders and diseases (NDDs) that are either chronically acquired or triggered by a singular detrimental event are a rapidly growing cause of disability and/or death. In recent times, there have been major advancements in our understanding of various neurodegenerative disease states that have revealed common pathologic features or mechanisms. The many mechanistic parallels discovered between various neurodegenerative diseases suggest that a single therapeutic approach may be used to treat multiple disease conditions. Of late, natural compounds and supplemental substances have become an increasingly attractive option to treat NDDs because there is growing evidence that these nutritional constituents have potential adjunctive therapeutic effects (be it protective or restorative) on various neurodegenerative diseases. Here we review relevant experimental and clinical data on supplemental substances (i.e., curcuminoids, rosmarinic acid, resveratrol, acetyl-L-carnitine, and omega-3 (n-3) polyunsaturated fatty acids) that have demonstrated encouraging therapeutic effects on chronic diseases, such as Alzheimer's disease and neurodegeneration resulting from acute adverse events, such as traumatic brain injury.
引用
收藏
页码:394 / 403
页数:10
相关论文
共 156 条
[61]   Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT) [J].
Ishrat, Tauheed ;
Hoda, Md Nasrul ;
Khan, M. Badruzzaman ;
Yousuf, Seema ;
Ahmad, Muzamil ;
Khan, Mohd Moshahid ;
Ahmad, Ajmal ;
Islam, Fakhrul .
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 19 (09) :636-647
[62]   Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death [J].
Jang, JH ;
Surh, YJ .
FREE RADICAL BIOLOGY AND MEDICINE, 2003, 34 (08) :1100-1110
[63]   Cancer chemopreventive activity of resveratrol, a natural product derived from grapes [J].
Jang, MS ;
Cai, EN ;
Udeani, GO ;
Slowing, KV ;
Thomas, CF ;
Beecher, CWW ;
Fong, HHS ;
Farnsworth, NR ;
Kinghorn, AD ;
Mehta, RG ;
Moon, RC ;
Pezzuto, JM .
SCIENCE, 1997, 275 (5297) :218-220
[64]   ACTIVITY OF L-CARNITINE AND L-ACETYLCARNITINE ON CHOLINOCEPTIVE NEOCORTICAL NEURONS OF THE RAT INVIVO [J].
JANIRI, L ;
FALCONE, M ;
PERSICO, A ;
TEMPESTA, E .
JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION, 1991, 86 (02) :135-146
[65]   Correlation between level of (n-3) polyunsaturated fatty acids in brain phospholipids and learning ability in rats. A multiple generation study [J].
Jensen, MM ;
Skarsfeldt, T ;
Hoy, CE .
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1300 (03) :203-209
[66]   Acylcarnitines: Role in brain [J].
Jones, Lauren L. ;
McDonald, David A. ;
Borum, Peggy R. .
PROGRESS IN LIPID RESEARCH, 2010, 49 (01) :61-75
[67]   Nutrition, Brain Aging, and Neurodegeneration [J].
Joseph, James ;
Cole, Greg ;
Head, Elizabeth ;
Ingram, Donald .
JOURNAL OF NEUROSCIENCE, 2009, 29 (41) :12795-12801
[68]   Dietary intake of fatty acids and fish in relation to cognitive performance at middle age [J].
Kalmijn, S ;
van Boxtel, MPJ ;
Ocké, M ;
Verschuren, WMM ;
Kromhout, D ;
Launer, LJ .
NEUROLOGY, 2004, 62 (02) :275-280
[69]   Cerebrospinal fluid profile of amyloid β42 (Aβ42), hTau and ubiquitin in North Indian Alzheimer's disease patients [J].
Kandimalla, Ramesh J. L. ;
Prabhakar, S. ;
Binukumar, B. K. ;
Wani, Willayat Yousuf ;
Sharma, Deep Raj ;
Grover, V. K. ;
Bhardwaj, Neerja ;
Jain, Kajal ;
Gill, Kiran Dip .
NEUROSCIENCE LETTERS, 2011, 487 (02) :134-138
[70]   Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease [J].
Karuppagounder, Saravanan S. ;
Pinto, John T. ;
Xu, Hui ;
Chen, Huan-Lian ;
Beal, M. Flint ;
Gibson, Gary E. .
NEUROCHEMISTRY INTERNATIONAL, 2009, 54 (02) :111-118