Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery

被引：60

作者：

Ansarin, Mohssen ^{[1
]}

Cattaneo, Augusto ^{[1
]}

De Benedetto, Luigi ^{[1
]}

Zorzi, Stefano ^{[1
]}

Lombardi, Francesca ^{[2
]}

Alterio, Daniela ^{[3
]}

Rocca, Maria Cossu ^{[4
]}

Scelsi, Daniele ^{[1
]}

Preda, Lorenzo ^{[5
]}

Chiesa, Fausto ^{[1
]}

Santoro, Luigi ^{[6
]}

机构：

[1] European Inst Oncol, Dept Otolaryngol Head & Neck Surg, Via Ripamonti 435, I-20141 Milan, Italy

[2] European Inst Oncol, Div Pathol, Milan, Italy

[3] European Inst Oncol, Div Radiotherapy, Milan, Italy

[4] European Inst Oncol, Med Oncol Div Urogenital & Head & Neck Tumours, Milan, Italy

[5] European Inst Oncol, Div Radiol, Milan, Italy

[6] European Inst Oncol, Div Epidemiol & Biostat, Milan, Italy

来源：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2017年 / 39卷 / 01期

关键词：

laryngeal cancer; transoral laryngeal microsurgery; organ preservation; relapse-free survival; overall survival; QUALITY-OF-LIFE; ADVANCED LARYNGEAL-CANCER; SQUAMOUS-CELL CARCINOMA; CARBON-DIOXIDE LASER; LOCAL-CONTROL; ORGAN-PRESERVATION; RADIOTHERAPY; SURGERY; CO2-LASER; CORDECTOMY;

D O I：

10.1002/hed.24534

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background. The purpose of this study was to identify the factors influencing oncologic outcomes for patients with early-intermediate glottic cancer treated by transoral laser microsurgery (TLM). Methods. This was a retrospective mono-institutional study. A total of 590 patients with cTis-cT3 glottic cancer underwent TLM with curative intent. Results. TLM alone was performed in 538 patients (91.2%) and TLM followed by adjuvant radiotherapy (RT) was done in 52 (8.8%). Five-year recurrence-free survival (RFS) and 10-year overall survival (OS) were 85.3% and 74.7%, respectively. The larynx-preservation ratio was 95.9%. In particular, from our data, we found that occult metastases were rare (1.2%); preventive tracheotomy was not necessary; the local recurrence rate of Tis was similar to that in the T2 and T3 group; and no major or lethal complications were observed. Conclusion. Age (> 60 vs <= 60), type of cordectomy (>= IV vs <= III), status of margins, fixed arytenoid, and pathologic T classification, were the variables associated with RFS, OS, and organ-preservation rate. (C) 2016 Wiley Periodicals.

引用

页码：71 / 81

页数：11

共 24 条

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