Regression of fibrosis after HBV antiviral therapy. Is cirrhosis reversible?

被引：57
作者：
Calvaruso, Vincenza [1 ]
Craxi, Antonio [1 ]
机构：
[1] Univ Palermo, Gastroenterol & Hepatol Unit, I-90127 Palermo, Italy
来源：
LIVER INTERNATIONAL | 2014年 / 34卷
关键词：
antiviral therapy; chronic hepatitis B; hepatocellular carcinoma; liver fibrosis; CHRONIC HEPATITIS-B; TENOFOVIR DISOPROXIL FUMARATE; VIRUS-RELATED CIRRHOSIS; ADEFOVIR DIPIVOXIL; HEPATOCELLULAR-CARCINOMA; INTERFERON THERAPY; NATURAL-HISTORY; LIVER-DISEASE; DECOMPENSATED CIRRHOSIS; COMPENSATED CIRRHOSIS;
D O I：
10.1111/liv.12395
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Long-lasting HBV-DNA suppression is considered to be the best surrogate end-point of antiviral therapy in patients with hepatitis B virus (HBV) related chronic hepatitis or cirrhosis, and it is a prerequisite to prevent liver-related complications and improve survival. Treatment with oral antiviral drugs in patients with HBV cirrhosis is effective in restoring liver function and improving survival even in those with decompensated cirrhosis. These agents are generally well-tolerated for long-term treatment, and several evidences have demonstrated that they are able to reverse liver fibrosis and prevent the occurrence of HCC.
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页码：85 / 90
页数：6
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