Rational Design of an Organometallic Glutathione Transferase Inhibitor

被引：166

作者：

Ang, Wee Han ^{[1
]}

Parker, Lorien J. ^{[2
]}

De Luca, Anastasia ^{[3
]}

Juillerat-Jeanneret, Lucienne ^{[4
]}

Morton, Craig J. ^{[2
]}

Lo Bello, Mario ^{[3
]}

Parker, Michael W. ^{[2
]}

Dyson, Paul J. ^{[1
]}

机构：

[1] Ecole Polytech Fed Lausanne, Inst Sci & Ingn Chim, CH-1015 Lausanne, Switzerland

[2] St Vincents Inst Med Res, Biota Struct Biol Lab, Fitzroy, Vic 3065, Australia

[3] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[4] CHU Vaudois, Univ Inst Pathol, CH-1011 Lausanne, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2009年 / 48卷 / 21期

基金：

澳大利亚研究理事会; 瑞士国家科学基金会; 英国医学研究理事会;

关键词：

bioorganometallic chemistry; chemical biology; inhibitors; transferases; HALF-SANDWICH COMPLEXES; S-TRANSFERASES; IN-VITRO; P1-1; DRUGS; SITE; RAT;

D O I：

10.1002/anie.200900185

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Double trouble: A hybrid organic-inorganic (organometallic) inhibitor was designed to target glutathione transferases. The metal center is used to direct protein binding, while the organic moiety acts as the active-site inhibitor (see picture). The mechanism of inhibition was studied using a range of biophysical and biochemical methods. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：3854 / 3857

页数：4

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