Terahertz pulsed spectroscopy of paraffin-embedded brain glioma

被引：119

作者：

Meng, Kun ^{[1
,2
]}

Chen, Tu-nan ^{[1
,3
]}

Chen, Tao ^{[1
]}

Zhu, Li-guo ^{[1
,2
]}

Liu, Qiao ^{[1
,2
]}

Li, Zhao ^{[3
]}

Li, Fei ^{[3
]}

Zhong, Sen-cheng ^{[1
,2
]}

Li, Ze-ren ^{[1
,2
]}

Feng, Hua ^{[3
]}

Zhao, Jian-heng ^{[1
]}

机构：

[1] China Acad Engn Phys, Inst Fluid Phys, Interdisciplinary Lab Phys & Biomed, Mianyang 621900, Sichuan, Peoples R China

[2] China Acad Engn Phys, Terahertz Res Ctr, Mianyang 621900, Sichuan, Peoples R China

[3] Third Mil Med Univ, Southwest Hosp, Dept Neurosurg, Chongqing 400038, Peoples R China

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2014年 / 19卷 / 07期

关键词：

spectroscopy; terahertz; tissue diagnostics; VIVO; TECHNOLOGY; PATHOLOGY;

D O I：

10.1117/1.JBO.19.7.077001

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The refractive indices, absorption coefficients, and complex dielectric constants of paraffin-embedded brain glioma and normal brain tissues have been measured by a terahertz time-domain spectroscopy (THz-TDS) system in the 0.2- to 2.0-THz range. The spectral differences between gliomas and normal brain tissues were obtained. Compared with normal brain tissue, our results indicate that paraffin-embedded brain gliomas have a higher refractive index, absorption coefficient, and dielectric constant. Based on these results, the best THz frequencies for different methods of paraffin-embedded brain glioma imaging, such as intensity imaging, coherent imaging with continuum THz sources, and THz pulsed imaging with short-pulsed THz sources, are analyzed. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License.

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