Soluble, antigen-specific T-cell proteins: T-cell-based humoral immunity?

被引:7
作者
Cone, RE [1 ]
Malley, A [1 ]
机构
[1] OREGON REG PRIMATE RES CTR,BEAVERTON,OR 97006
来源
IMMUNOLOGY TODAY | 1996年 / 17卷 / 07期
关键词
D O I
10.1016/0167-5699(96)10021-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The existence of extracellular, antigen-specific, T-cell factors has been a subject of heated debate ova the years. Here, Robert Cone and Arthur Malley consider the nature of the structural and functional properties of these T-cell-derived proteins, particularly their similarity to T-cell receptor alpha chains and their extremely high specific activity. A genetic origin and mode of action of these factors in immunoregulation is proposed based on existing experimental data.
引用
收藏
页码:318 / 322
页数:5
相关论文
共 53 条
[1]   MESSENGER-RNA FOR AN ANTIGEN-SPECIFIC BINDING MOLECULE FROM AN ANTIGEN-SPECIFIC T-CELL HYBRID [J].
BEAMAN, KD ;
RUDDLE, NH ;
BOTHWELL, ALM ;
CONE, RE .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (05) :1524-1528
[2]  
BEHLKE MA, 1976, NATURE, V322, P379
[3]   SHARED IDIOTYPIC DETERMINANTS ON B AND T-LYMPHOCYTES REACTIVE AGAINST SAME ANTIGENIC DETERMINANTS .5. BIOCHEMICAL AND SEROLOGICAL CHARACTERISTICS OF NATURALLY OCCURRING, SOLUBLE ANTIGEN-BINDING T-LYMPHOCYTE-DERIVED MOLECULES [J].
BINZ, H ;
WIGZELL, H .
SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1976, 5 (05) :559-571
[4]  
BLOOM BR, 1992, ANNU REV IMMUNOL, V10, P453, DOI 10.1146/annurev.iy.10.040192.002321
[5]   SOLID-PHASE ANTIGEN-BINDING BY PURIFIED IMMUNOPROTEINS FROM ANTIGEN-SPECIFIC MONOCLONAL T-CELL HYBRIDOMAS [J].
BRISTOW, CL ;
MARCHALONIS, JJ .
MOLECULAR IMMUNOLOGY, 1989, 26 (07) :611-624
[6]  
CHEN YH, 1994, J IMMUNOL, V152, P3
[7]   CHARACTERIZATION OF SUPPRESSOR T-CELL CLONES DERIVED FROM A MOUSE TOLERIZED WITH CONJUGATES OF OVALBUMIN AND MONOMETHOXYPOLYETHYLENE GLYCOL [J].
CHEN, YH ;
TAKATA, M ;
MAITI, PK ;
RECTOR, ES ;
SEHON, AH .
CELLULAR IMMUNOLOGY, 1992, 142 (01) :16-27
[8]   AN APPROACH TO THE UNIFICATION OF SUPPRESSOR T-CELL CIRCUITS - A SIMPLIFIED ASSAY FOR THE INDUCTION OF SUPPRESSION BY T-CELL-DERIVED, ANTIGEN-BINDING MOLECULES (T-ABM) [J].
CHUE, B ;
FERGUSON, TA ;
BEAMAN, KD ;
ROSENMAN, SJ ;
CONE, RE ;
FLOOD, PM ;
GREEN, DR .
CELLULAR IMMUNOLOGY, 1989, 118 (01) :30-40
[9]  
Cone R E, 1988, Int Rev Immunol, V3, P205, DOI 10.3109/08830188809051189
[10]   ANTIGEN BINDING SPECIFICITY OF CELL-SURFACE IMMUNOGLOBULIN ISOLATED FROM T (HELPER) CELLS [J].
CONE, RE ;
MARCHALONIS, JJ .
AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 1973, 51 (OCT) :689-700