Zinc effects on hyperglycemia and hypoleptinemia in streptozotocin-induced diabetic mice

被引：51
作者：
Chen, MD
Song, YM
Lin, PY
机构：
[1] Taichung Vet Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taichung 40705, Taiwan
[2] Tunghai Univ, Dept Biol, Taichung 40704, Taiwan
[3] Tunghai Univ, Dept Chem, Taichung 40704, Taiwan
来源：
HORMONE AND METABOLIC RESEARCH | 2000年 / 32卷 / 03期
关键词：
leptin; hyperphagia; diabetic mice; tumor necrosis factor;
D O I：
10.1055/s-2007-978600
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Zinc has an antihyperglycemic effect. Zinc can also influence the production of leptin, a satiety factor that reduces appetite and blood sugar level. In this study, we investigated the effect of zinc supplementation on food intake and circulating leptin and glucose concentrations in streptozotocin-induced diabetic mice. Male diabetic mice received zinc supplementation (20 ppm) from drinking water for two weeks. The results showed that zinc treatment did not affect body weight gain, body fat content or food intake in these diabetic mice. However, zinc supplementation markedly ameliorated the hyperglycemia of diabetic mice. After zinc treatment, serum leptin concentrations tended to increase in the diabetic mice. This study suggests that zinc is a mediator of leptin production.
引用
收藏
页码：107 / 109
页数：3
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