Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep

被引:53
作者
Dai, Xi-Jian [1 ,2 ]
Jiang, Jian [2 ]
Zhang, Zhiqiang [1 ]
Nie, Xiao [2 ,3 ]
Liu, Bi-Xia [4 ]
Pei, Li [2 ]
Gong, Honghan [2 ]
Hu, Jianping [1 ]
Lu, Guangming [1 ]
Zhan, Yang [5 ]
机构
[1] Nanjing Univ, Jinling Hosp, Sch Med, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China
[2] Nanchang Univ, Affiliated Hosp 1, Dept Radiol, Nanchang, Peoples R China
[3] Yiyang Cent Hosp, Dept Radiol, Yiyang, Peoples R China
[4] Jiangxi Canc Hosp, Dept ICU, Nanchang, Jiangxi, Peoples R China
[5] Chinese Acad Sci, Shenzhen Inst Adv Technol, Brain Cognit & Brain Dis Inst, Shenzhen, Peoples R China
来源
FRONTIERS IN PSYCHIATRY | 2018年 / 9卷
基金
中国国家自然科学基金;
关键词
insomnia; sleep deprivation; voxel-based morphometry; gray matter; attention network test; spatial working memory; CHRONIC PRIMARY INSOMNIA; RESTING-STATE FMRI; MOUSE CEREBRAL-CORTEX; GENE-EXPRESSION; FUNCTIONAL CONNECTIVITY; ATTENTIONAL NETWORKS; HIPPOCAMPAL VOLUME; GENDER-DIFFERENCES; DEPRIVATION; WAKEFULNESS;
D O I
10.3389/fpsyt.2018.00266
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Insufficient sleep is common in daily life and can lead to cognitive impairment. Sleep disturbance also exists in neuropsychiatric diseases. However, whether and how acute and chronic sleep loss affect brain morphology remain largely unknown. Methods: We used voxel-based morphology method to study the brain structural changes during sleep deprivation (SD) at six time points of rested wakefulness, 20, 24, 32, 36 h SD, and after one night sleep in 22 healthy subjects, and in 39 patients with chronic primary insomnia relative to 39 status-matched good sleepers. Attention network and spatial memory tests were performed at each SD time point in the SD Procedure. The longitudinal data were analyzed using one-way repeated measures ANOVA, and post-hoc analysis was used to determine the between-group differences. Results: Acute SD is associated with widespread gray matter volume (GMV) changes in the thalamus, cerebellum, insula and parietal cortex. Insomnia is associated with increased GMV in temporal cortex, insula and cerebellum. Acute SD is associated with brain atrophy and as SD hours prolong more areas show reduced GMV, and after one night sleep the brain atrophy is restored and replaced by increased GMV in brain areas. SD has accumulative negative effects on attention and working memory. Conclusions: Acute SD and insomnia exhibit distinct morphological changes of GMV. SD has accumulative negative effects on brain morphology and advanced cognitive function. The altered GMV may provide neurobiological basis for attention and memory impairments following sleep loss.
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页数:16
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