The Hypothalamic-Pituitary-Adrenal Axis: A Brief History

被引：69
作者：
Miller, Walter L. [1 ,2 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat, Ctr Reprod Sci, 513 Parnassus Ave, San Francisco, CA 94143 USA
[2] Univ Calif San Francisco, Inst Human Genet, 513 Parnassus Ave, San Francisco, CA 94143 USA
来源：
HORMONE RESEARCH IN PAEDIATRICS | 2018年 / 89卷 / 04期
关键词：
Adrenocorticotropic hormone; Corticotropin-releasing hormone; Endocrinology; Feedback loop; Receptors; Steroids; CORTICOTROPIN-RELEASING-FACTOR; CENTRAL-NERVOUS-SYSTEM; BETA-CORTICOTROPIN; ANTERIOR-PITUITARY; GLUCOCORTICOID-RECEPTOR; MELANOCORTIN RECEPTOR; CUSHINGS-SYNDROME; COMMON PRECURSOR; ADRENOCORTICOTROPIC HORMONE; MINERALOCORTICOID RECEPTOR;
D O I：
10.1159/000487755
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The hypothalamic-pituitary-adrenal (HPA) axis is central to homeostasis, stress responses, energy metabolism, and neuropsychiatric function. The history of this complex system involves discovery of the relevant glands (adrenal, pituitary, hypothalamus), hormones (cortisol, corticotropin, corticotropin-releasing hormone), and the receptors for these hormones. The adrenal and pituitary were identified by classical anatomists, but most of this history has taken place rather recently, and has involved complex chemistry, biochemistry, genetics, and clinical investigation. The integration of the HPA axis with modern neurology and psychiatry has cemented the role of endocrinology in contemporary studies of behavior. (C) 2018 S. Karger AG, Basel.
引用
收藏
页码：212 / 223
页数：12
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