The GH-IGF-I axis in children with idiopathic short stature

被引：32

作者：

Blair, JC ^{[1
]}

Savage, MO ^{[1
]}

机构：

[1] St Bartholomews & Royal London Sch Med & Dent, Dept Endocrinol, Sect Paediat Endocrinol, London EC1A 7BE, England

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2002年 / 13卷 / 08期

关键词：

D O I：

10.1016/S1043-2760(02)00631-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Idiopathic short stature (ISS) is a term used for children in whom the etiology of the short stature is undefined. Investigations of the growth hormone (GH)-insulin-like growth factor I axis have revealed several molecular and endocrinological defects in ISS patients. Abnormalities of GH secretion and action, although not frequent, will help to categorize some children with ISS. Because most diagnostic methods remain crude, however, their modification might be necessary to identify more subtle and yet functionally significant abnormalities of this endocrine axis.

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页码：325 / 330

页数：6

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