Biomimetic Total Synthesis of Scabellone B

被引：2
|
作者：
Yu, Tao [1 ]
Shu, Xin [1 ]
Yang, Kewu [1 ]
Hu, Xiangdong [1 ]
机构：
[1] Northwest Univ, Dept Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ China, Xian 710127, Shaanxi, Peoples R China
来源：
SYNLETT | 2018年 / 29卷 / 12期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
total synthesis; protecting groups; dimerization; electrocyclic reactions; natural products; NEUTROPHIL RESPIRATORY BURST; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; TECOMAQUINONE-I; POPOLOHUANONE-E; INHIBITORS; DIMERIZATION; EFFICIENT; FARNESYLTRANSFERASE; THIAPLIDIAQUINONES;
D O I：
10.1055/s-0037-1610178
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A biomimetic total synthesis of scabellone B is described. Through sequential regioselective introduction of a geranyl group by means of silyl protection, oxidative dimerization, and biomimetic oxo-6 electrocyclization with good cyclization selectivity, a biomimetic approach to scabellone B was achieved in five steps and 32% overall yield.
引用
收藏
页码：1617 / 1621
页数：5
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