Synthesis of novel symmetrical 2-oxo-spiro[indole-3,4′-pyridines] by a reaction of oxindoles with 1,2-diaza-1,3-dienes

被引：17
作者：
Attanasi, Orazio A. [1 ]
Campisi, Linda A. [1 ]
De Crescentini, Lucia [1 ]
Favi, Gianfranco [1 ]
Mantellini, Fabio [1 ]
机构：
[1] Univ Urbino Carlo Bo, Sect Organ Chem & Organ Nat Cpds, Dept Biomol Sci, I-61029 Urbino, PU, Italy
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 01期
关键词：
ONE-POT; FUNCTIONALIZED PYRROLES; 3-COMPONENT REACTION; ORGANIC-SYNTHESIS; METAL-IONS; ROUTE; 3-OXOALKANAMIDES; SPIROINDOLONES; CONSTRUCTION; DERIVATIVES;
D O I：
10.1039/c4ob01959h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple reaction of some oxindole derivatives with 1,2-diaza-1,3-dienes to produce 2-oxo-spiro[indole-3,4'-pyridines] in good yields is described here. This transformation represents a practical two steps approach to new and biologically interesting 2-oxo-spiro[indole-3,4'-pyridine] scaffolds using a double Michael addition/cyclization sequence.
引用
收藏
页码：277 / 282
页数：6
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