Chemotherapy and chemo-resistance in nasopharyngeal carcinoma

被引：110

作者：

Guan, Shuzhen ^{[1
]}

Wei, Jinrui ^{[2
]}

Huang, Lingkun ^{[1
]}

Wu, Lichuan ^{[1
]}

机构：

[1] Guangxi Univ, Med Coll, Nanning 530004, Peoples R China

[2] Guangxi Univ Chinese Med, Guangxi Sci Res Ctr Tradit Chinese Med, Nanning, Guangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 207卷

关键词：

Nasopharyngeal carcinoma; Chemotherapy; Chemo-resistance; Epstein-Barr virus; EPSTEIN-BARR-VIRUS; EPITHELIAL-MESENCHYMAL TRANSITION; INTENSITY-MODULATED RADIOTHERAPY; GUIDELINES(R) INSIGHTS HEAD; PHASE-II; MULTIDRUG-RESISTANCE; CISPLATIN RESISTANCE; DOWN-REGULATION; 8TH EDITION; FIBROBLASTS PROMOTE;

D O I：

10.1016/j.ejmech.2020.112758

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) and occurs frequently in the south of China and Southeast Asian countries. Concurrent chemo-radiotherapy is one of the main treatments for NPC. Although, the combined treatment of chemo-radiotherapy produces a satisfying survival rate, the chemo-resistance arises as a big obstacle in curing recurrent NPC patients. The acquirement of chemo-resistance is usually along with a poor prognosis. So far, the mechanism of chemo-resistance in NPC has not been fully elucidated and there have not been a comprehensive review on this issue. Thus, it is of great significance to summarize the mechanisms involved in NPC chemoresistance. In this review, the importance and limitations of chemotherapy and the mechanisms of chemo-resistances in NPC were discussed. (C) 2020 Elsevier Masson SAS. All rights reserved.

引用

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