Chemotherapy and chemo-resistance in nasopharyngeal carcinoma

被引：110
作者：
Guan, Shuzhen [1 ]
Wei, Jinrui [2 ]
Huang, Lingkun [1 ]
Wu, Lichuan [1 ]
机构：
[1] Guangxi Univ, Med Coll, Nanning 530004, Peoples R China
[2] Guangxi Univ Chinese Med, Guangxi Sci Res Ctr Tradit Chinese Med, Nanning, Guangxi, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2020年 / 207卷
关键词：
Nasopharyngeal carcinoma; Chemotherapy; Chemo-resistance; Epstein-Barr virus; EPSTEIN-BARR-VIRUS; EPITHELIAL-MESENCHYMAL TRANSITION; INTENSITY-MODULATED RADIOTHERAPY; GUIDELINES(R) INSIGHTS HEAD; PHASE-II; MULTIDRUG-RESISTANCE; CISPLATIN RESISTANCE; DOWN-REGULATION; 8TH EDITION; FIBROBLASTS PROMOTE;
D O I：
10.1016/j.ejmech.2020.112758
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Nasopharyngeal carcinoma (NPC) is closely associated with Epstein-Barr virus (EBV) and occurs frequently in the south of China and Southeast Asian countries. Concurrent chemo-radiotherapy is one of the main treatments for NPC. Although, the combined treatment of chemo-radiotherapy produces a satisfying survival rate, the chemo-resistance arises as a big obstacle in curing recurrent NPC patients. The acquirement of chemo-resistance is usually along with a poor prognosis. So far, the mechanism of chemo-resistance in NPC has not been fully elucidated and there have not been a comprehensive review on this issue. Thus, it is of great significance to summarize the mechanisms involved in NPC chemoresistance. In this review, the importance and limitations of chemotherapy and the mechanisms of chemo-resistances in NPC were discussed. (C) 2020 Elsevier Masson SAS. All rights reserved.
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页数：11
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共 179 条
  • [1] NCCN Guidelines® Insights Head and Neck Cancers, Version 2.2017
    Adelstein, David
    Gillison, Maura L.
    Pfister, David G.
    Spencer, Sharon
    Adkins, Douglas
    Brizel, David M.
    Burtness, Barbara
    Busse, Paul M.
    Caudell, Jimmy J.
    Cmelak, Anthony J.
    Colevas, A. Dimitrios
    Eisele, David W.
    Fenton, Moon
    Foote, Robert L.
    Gilbert, Jill
    Haddad, Robert I.
    Hicks, Wesley L., Jr.
    Hitchcock, Ying J.
    Jimeno, Antonio
    Leizman, Debra
    Lydiatt, William M.
    Maghami, Ellie
    Mell, Loren K.
    Mittal, Bharat B.
    Pinto, Harlan A.
    Ridge, John A.
    Rocco, James
    Rodriguez, Cristina P.
    Shah, Jatin P.
    Weber, Randal S.
    Witek, Matthew
    Worden, Frank
    Yom, Sue S.
    Zhen, Weining
    Burns, Jennifer L.
    Darlow, Susan D.
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2017, 15 (06): : 761 - 770
  • [2] The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more "personalized" approach to cancer staging
    Amin, Mahul B.
    Greene, Frederick L.
    Edge, Stephen B.
    Compton, Carolyn C.
    Gershenwald, Jeffrey E.
    Brookland, Robert K.
    Meyer, Laura
    Gress, Donna M.
    Byrd, David R.
    Winchester, David P.
    [J]. CA-A CANCER JOURNAL FOR CLINICIANS, 2017, 67 (02) : 93 - 99
  • [3] Bray Freddie, 2018, CA Cancer J Clin, V68, P394, DOI [10.3322/caac.21609, 10.3322/caac.21492]
  • [4] EBV-encoded miRNAs
    Barth, Stephanie
    Meister, Gunter
    Graesser, Friedrich A.
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2011, 1809 (11-12): : 631 - 640
  • [5] Dysregulation of the MiR-449b target TGFBI alters the TGFβ pathway to induce cisplatin resistance in nasopharyngeal carcinoma
    Bissey, Pierre-Antoine
    Law, Jacqueline H.
    Bruce, Jeff P.
    Shi, Wei
    Renoult, Aline
    Chua, Melvin L. K.
    Yip, Kenneth W.
    Liu, Fei-Fei
    [J]. ONCOGENESIS, 2018, 7
  • [6] Chemotherapy and radiotherapy in nasopharyngeal carcinoma: an update of the MAC-NPC meta-analysis
    Blanchard, Pierre
    Lee, Anne
    Marguet, Sophie
    Leclercq, Julie
    Ng, Wai Tong
    Ma, Jun
    Chan, Anthony T. C.
    Huang, Pei-Yu
    Benhamou, Ellen
    Zhu, Guopei
    Chua, Daniel T. T.
    Chen, Yong
    Mai, Hai-Qiang
    Kwong, Dora L. W.
    Cheah, Shie Lee
    Moon, James
    Tung, Yuk
    Chi, Kwan-Hwa
    Fountzilas, George
    Zhang, Li
    Hui, Edwin Pun
    Lu, Tai-Xiang
    Bourhis, Jean
    Pignon, Jean Pierre
    [J]. LANCET ONCOLOGY, 2015, 16 (06) : 645 - 655
  • [7] Long Noncoding RNAs as Biomarkers in Cancer
    Bolha, Luka
    Ravnik-Glavac, Metka
    Glavac, Damjan
    [J]. DISEASE MARKERS, 2017, 2017
  • [8] EBV-miR-BART7-3p promotes the EMT and metastasis of nasopharyngeal carcinoma cells by suppressing the tumor suppressor PTEN
    Cai, L-M
    Lyu, X-M
    Luo, W-R
    Cui, X-F
    Ye, Y-F
    Yuan, C-C
    Peng, Q-X
    Wu, D-H
    Liu, T-F
    Wang, E.
    Marincola, F-M
    Yao, K-T
    Fang, W-Y
    Cai, H-B
    Li, X.
    [J]. ONCOGENE, 2015, 34 (17) : 2156 - 2166
  • [9] EBV-miR-BART7-3p Imposes Stemness in Nasopharyngeal Carcinoma Cells by Suppressing SMAD7
    Cai, Longmei
    Long, Yufei
    Chong, Tuotuo
    Cai, Wenzhi
    Tsang, Chi Man
    Zhou, Xiaohan
    Lin, Yanling
    Ding, Tengteng
    Zhou, Wenyan
    Zhao, Hongli
    Chen, Yuxiang
    Wang, Jianguo
    Lyu, Xiaoming
    Cho, William C.
    Li, Xin
    [J]. FRONTIERS IN GENETICS, 2019, 10
  • [10] Epstein-Barr virus-encoded microRNA BART1 induces tumour metastasis by regulating PTEN-dependent pathways in nasopharyngeal carcinoma
    Cai, Longmei
    Ye, Yanfen
    Jiang, Qiang
    Chen, Yuxiang
    Lyu, Xiaoming
    Li, Jinbang
    Wang, Shuang
    Liu, Tengfei
    Cai, Hongbing
    Yao, Kaitai
    Li, Ji-Liang
    Li, Xin
    [J]. NATURE COMMUNICATIONS, 2015, 6
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