A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease

被引：603

作者：

Haes, AJ

Hall, WP

Chang, L

Klein, WL

Van Duyne, RP

机构：

[1] Northwestern Univ, Dept Chem, Evanston, IL 60208 USA

[2] Northwestern Univ, Dept Neurobiol & Physiol, Evanston, IL 60208 USA

来源：

NANO LETTERS | 2004年 / 4卷 / 06期

关键词：

D O I：

10.1021/nl049670j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The localized surface plasmon resonance (LSPR) nanosensor based on the optical properties of Ag nanotriangles is shown to aid in the understanding of the interaction between amyloid beta-derived diffusible ligands (ADDL) and the anti-ADDL antibody, molecules possibly involved in the development of Alzheimer's disease. By varying the concentration of anti-ADDL antibody, a surface confined binding constant of 3.0 x 10(7) M-1 for the interaction of ADDLs and anti-ADDLs was measured. Influences of Cr, the nanoparticle adhesion layer, will be shown to be the limiting factor in the sensitivity of this assay. This is the first nonmodel application of the LSPR nanosensor.

引用

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页码：1029 / 1034

页数：6

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