Targeting the signaling in Epstein-Barr virus-associated diseases: mechanism, regulation, and clinical study

被引：76

作者：

Cao, Ya ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Xie, Longlong ^{[1
,2
,3
,4
]}

Shi, Feng ^{[1
,2
,3
,4
]}

Tang, Min ^{[1
,2
,3
,4
,6
]}

Li, Yueshuo ^{[1
,2
,3
,4
]}

Hu, Jianmin ^{[1
,2
,3
,4
]}

Zhao, Lin ^{[1
,2
,3
,4
]}

Zhao, Luqing ^{[1
]}

Yu, Xinfang ^{[1
,2
,3
,4
]}

Luo, Xiangjian ^{[1
,2
,3
,4
,6
]}

Liao, Weihua ^{[8
]}

Bode, Ann M. ^{[9
]}

机构：

[1] Cent South Univ, Key Lab Carcinogenesis & Invas, Chinese Minist Educ, Dept Radiol,Xiangya Hosp, Changsha 410078, Peoples R China

[2] Cent South Univ, Xiangya Sch Med, Canc Res Inst, Changsha 410078, Peoples R China

[3] Cent South Univ, Xiangya Sch Med, Sch Basic Med Sci, Changsha 410078, Peoples R China

[4] Chinese Minist Hlth, Key Lab Carcinogenesis, Changsha 410078, Peoples R China

[5] Res Ctr Technol Nucle Acid Based Diagnost & Thera, Changsha 410078, Peoples R China

[6] Cent South Univ, Mol Imaging Res Ctr, Changsha 410008, Hunan, Peoples R China

[7] Natl Joint Engn Res Ctr Genet Diagnost Infect Dis, Changsha 410078, Peoples R China

[8] Cent South Univ, Dept Radiol, Xiangya Hosp, Changsha 410078, Peoples R China

[9] Univ Minnesota, Hormel Inst, Austin, MN 55912 USA

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

NASOPHARYNGEAL CARCINOMA-CELLS; ANTITUMOR NATURAL-PRODUCT; MEMBRANE-PROTEIN; DNAZYME ENHANCES RADIOSENSITIVITY; MUSHROOM ALBATRELLUS-CONFLUENS; SYSTEMIC-LUPUS-ERYTHEMATOSUS; SPONTANEOUS LYTIC INFECTION; NITRIC-OXIDE SYNTHASE; NUCLEAR ANTIGEN 1; PHASE-I TRIAL;

D O I：

10.1038/s41392-020-00376-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epstein-Barr virus-associated diseases are important global health concerns. As a group I carcinogen, EBV accounts for 1.5% of human malignances, including both epithelial- and lymphatic-originated tumors. Moreover, EBV plays an etiological and pathogenic role in a number of non-neoplastic diseases, and is even involved in multiple autoimmune diseases (SADs). In this review, we summarize and discuss some recent exciting discoveries in EBV research area, which including DNA methylation alterations, metabolic reprogramming, the changes of mitochondria and ubiquitin-proteasome system (UPS), oxidative stress and EBV lytic reactivation, variations in non-coding RNA (ncRNA), radiochemotherapy and immunotherapy. Understanding and learning from this advancement will further confirm the far-reaching and future value of therapeutic strategies in EBV-associated diseases.

引用

页数：33

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