The unfolded protein response (UPR) pathway in Cryptococcus

被引：25

作者：

Cheon, Seon Ah ^{[1
,2
,3
]}

Jung, Kwang-Woo ^{[4
]}

Bahn, Yong-Sun ^{[4
]}

Kang, Hyun Ah ^{[1
]}

机构：

[1] Chung Ang Univ, Dept Life Sci, Res Ctr Biomol & Biosyst, Coll Nat Sci, Seoul 156756, South Korea

[2] Seoul Natl Univ, Dept Agr Biotechnol, Seoul, South Korea

[3] Seoul Natl Univ, Ctr Fungal Pathogenesis, Seoul, South Korea

[4] Yonsei Univ, Dept Biotechnol, Ctr Fungal Pathogenesis, Seoul 120749, South Korea

来源：

VIRULENCE | 2014年 / 5卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Cryptococcus neoformans; ER stress; unfolded protein response; Ire1; Hxl1; ENDOPLASMIC-RETICULUM STRESS; MESSENGER-RNA; TRANSCRIPTION FACTOR; HOST TEMPERATURE; ER STRESS; NEOFORMANS; VIRULENCE; KINASE; DEGRADATION; CALCINEURIN;

D O I：

10.4161/viru.26774

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unique and evolutionarily conserved signaling pathways allow an organism to sense, respond to, and adapt to internal and external environmental cues at its biological niche. In eukaryotic cells, the unfolded protein response (UPR) pathway regulates endoplasmic reticulum (ER) homeostasis upon exposure to environmental changes causing ER stress. The UPR pathway of Cryptococcus neoformans, an opportunistic fungal pathogen, which causes life-threatening meningoencephalitis in immunocompromised individuals, consists of the evolutionarily conserved Ire1 kinase, a unique bZIP transcription factor, Hxl1, and the ER-resident molecular chaperone Kar2/BiP. Although the Cryptococcus UPR pathway regulates ER stress, antifungal drug resistance, and virulence in an Ire1/Hxl1-dependent manner, Ire1 has Hxl1-independent roles in capsule biosynthesis and thermotolerance. In this review, we highlight the conserved and unique features of the Cryptococcus UPR pathway compared with other fungal UPR systems and its importance in the pathogenesis of cryptococcosis and discuss future challenges in this field.

引用

页码：341 / 350

页数：10

共 61 条

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