Characterization of in vitro and in vivo bioactivity of a ferulic acid-2-Hydroxypropyl-β-cyclodextrin inclusion complex

被引：45

作者：

Hsu, Chin-Mu ^{[1
]}

Yu, Song-Cu ^{[2
,3
]}

Tsai, Fuu-Jen ^{[4
,5
,6
]}

Tsai, Yuhsin ^{[2
,3
]}

机构：

[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Internal Med, Div Hematol & Oncol, Kaohsiung, Taiwan

[2] China Med Univ, Grad Inst Chinese Med, Taichung, Taiwan

[3] China Med Univ, Sch Chinese Med, 91 Hsueh Shih Rd, Taichung, Taiwan

[4] China Med Univ Hosp, Dept Med Res, Taichung, Taiwan

[5] China Med Univ Hosp, Dept Med Genet Pediat & Med Res, Taichung, Taiwan

[6] Asia Univ, Dept Biotechnol, Taichung, Taiwan

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2019年 / 180卷

关键词：

Ferulic acid; 2-Hydroxypropyl-beta-cyclodextrin; In vitro; In vivo; Bioactivity; OXIDATIVE STRESS; ACID; CYCLODEXTRIN; DELIVERY; EXTRACT;

D O I：

10.1016/j.colsurfb.2019.04.020

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Ferulic acid (FA) belongs to the family of phenolic acids and exhibits a wide variety of biological activities. However, the bioavailability of FA is not optimal, owing to its limited aqueous solubility. Several methods have been developed to increase FA bioavailability and enhance its cytoprotective effects. Complexing FA with cyclodextrins (CDs) may provide an alternative method to approach these goals. In this study, we prepared an FA-2-hydroxypropyl-beta-CD (FA-HP-beta-CD) complex, at a 1:1 M ratio of FA to HP-beta-CD, which was characterized by H-1 NMR, two-dimensional rotating frame spectroscopy and differential scanning calorimetry. Aqueous solubility of FA was improved after complexing with HP-beta-CD. Furthermore, in vitro and in vivo experimental results indicated that the FA-HP-beta-CD complex had greater bioactivity than FA alone. Therefore, we can conclude that the limitations of FA usage due to low aqueous solubility and bioavailability can be overcome by creating an HP-beta-CD inclusion complex with the hydrophobic FA.

引用

页码：68 / 74

页数：7

共 24 条

[1] L-Lysine Pro-Prodrug Containing trans-Ferulic Acid for 5-Amino Salicylic Acid Colon Delivery: Synthesis, Characterization and in Vitro Antioxidant Activity Evaluation [J].