CD146/sCD146 in the Pathogenesis and Monitoring of Angiogenic and Inflammatory Diseases

被引：20

作者：

Heim, Xavier ^{[1
,2
]}

Joshkon, Ahmad ^{[1
]}

Bermudez, Julien ^{[1
,3
]}

Bachelier, Richard ^{[1
]}

Dubrou, Clea ^{[1
]}

Boucraut, Jose ^{[2
,4
]}

Foucault-Bertaud, Alexandrine ^{[1
]}

Leroyer, Aurelie S. ^{[1
]}

Dignat-George, Francoise ^{[1
,5
]}

Blot-Chabaud, Marcel ^{[1
]}

Bardin, Nathalie ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, Inst Natl Sante & Rech Med INSERM, Inst Natl Rech Agr Alimentat & Environm INRAE, Hematol Dept,Ctr CardioVasc & Nutr Res C2VN,Fac P, Timone Campus, F-13005 Marseille, France

[2] Hop Conception, AP HM, Pole Biol, Serv Immunol, F-13005 Marseille, France

[3] North Hosp, AP HM, Dept Pulmonol, F-13015 Marseille, France

[4] North Hosp, AP HM, Lung Transplant Team, F-13015 Marseille, France

[5] Aix Marseille Univ, Timone Neurosci Inst, UMR CNRS 7289, F-13005 Marseille, France

来源：

BIOMEDICINES | 2020年 / 8卷 / 12期

关键词：

CD146; soluble CD146; inflammation angiogenesis; autoimmunity; ENDOTHELIAL PROGENITOR CELLS; CD4(+) T-CELLS; SOLUBLE CD146; ADHESION MOLECULES; INCREASED EXPRESSION; SYSTEMIC-SCLEROSIS; MARKER; MELANOMA; MCAM; MUC18;

D O I：

10.3390/biomedicines8120592

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD146 is a cell adhesion molecule expressed on endothelial cells, as well as on other cells such as mesenchymal stem cells and Th17 lymphocytes. This protein also exists in a soluble form, whereby it can be detected in biological fluids, including the serum or the cerebrospinal fluid (CSF). Some studies have highlighted the significance of CD146 and its soluble form in angiogenesis and inflammation, having been shown to contribute to the pathogenesis of many inflammatory autoimmune diseases, such as systemic sclerosis, mellitus diabetes, rheumatoid arthritis, inflammatory bowel diseases, and multiple sclerosis. In this review, we will focus on how CD146 and sCD146 contribute to the pathogenesis of the aforementioned autoimmune diseases and discuss the relevance of considering it as a biomarker in these pathologies.

引用

页码：1 / 13

页数：13

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