Differential Expression of Inflammatory Markers in Hypoglycemia Unawareness Associated with Type 1 Diabetes: A Case Report

被引:1
|
作者
Al Zoubi, Yousef [1 ,2 ]
Mussa, Bashair M. [2 ]
Srivastava, Ankita [1 ]
Mohammed, Abdul Khader [1 ]
Abdelgadir, Elamin [3 ]
Bashier, Alaaeldin [3 ]
Al Awadi, Fatheya [3 ]
Abusnana, Salah [4 ,5 ]
机构
[1] Univ Sharjah, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates
[2] Univ Sharjah, Coll Med, Basic Med Sci Dept, Sharjah 27272, U Arab Emirates
[3] Dubai Hlth Author, Dubai Hosp, Dubai 4545, U Arab Emirates
[4] Univ Hosp Sharjah, Dept Endocrinol & Diabet, Sharjah 72772, U Arab Emirates
[5] Univ Sharjah, Coll Med, Dept Clin Sci, Sharjah 72772, U Arab Emirates
关键词
hypoglycemia unawareness; type 1 diabetes mellitus; cytokines; inflammatory markers; TNF-α IL-1β IL-6; IFN-γ
D O I
10.3390/brainsci11010017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-alpha, IL-1 beta, IL-6, and IFN-gamma in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1 beta, IL-6, and IFN-gamma in T1DM patient with HU. However, the mRNA level of TNF-alpha showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.
引用
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页码:1 / 6
页数:6
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