Are antidepressants effective? A debate on their efficacy for the treatment of major depression in adults

被引:30
作者
Bschor, Tom [1 ,2 ]
Kilarski, Laura L. [3 ]
机构
[1] Schlosspark Hosp, Dept Psychiat, Heubnerweg 2, D-14059 Berlin, Germany
[2] Tech Univ Dresden, Univ Hosp, Dept Psychiat & Psychotherapy, D-01062 Dresden, Germany
[3] Univ Cologne, Fac Med, D-50931 Cologne, Germany
关键词
suicide; antidepressants; publication bias; randomized controlled trials; efficacy; switching antidepressants; placebo effect; RANDOMIZED CONTROLLED-TRIALS; SEROTONIN REUPTAKE INHIBITORS; PSYCHIATRY WFSBP GUIDELINES; CLINICAL-TRIALS; SUICIDE RATES; BIOLOGICAL TREATMENT; SYMPTOM REDUCTION; WORLD FEDERATION; PLACEBO; DISORDERS;
D O I
10.1586/14737175.2016.1155985
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Recently, the efficacy of antidepressants, a treatment used by 11% of US American adults, has been debated. Thousands of randomized controlled trials (RCTs) have been used to study antidepressants, with the majority demonstrating at least moderate superiority over placebo. In contrast, studies have found antidepressant effects to be unspecific and mainly resulting from placebo. The effects of antidepressants may also be overestimated due to selective publishing and selection of patients who have a high chance of response in RCTs. Studies have also shown the drugs do not reduce suicidal events when compared to placebo, and efficacy differences to placebo are often too small to prove clinical relevance. Here, we review the claims for and against antidepressant efficacy.
引用
收藏
页码:367 / 374
页数:8
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