Gardenia jasminoides Ellis ethanol extract and its constituents reduce the risks of gastritis and reverse gastric lesions in rats

被引：106

作者：

Lee, Je-Hyuk ^{[2
]}

Lee, Dong-Ung ^{[3
]}

Jeong, Choon-Sik ^{[1
]}

机构：

[1] Duksung Womens Univ, Coll Pharm, Seoul 132714, South Korea

[2] Duksung Womens Univ, Plant Resources Res Inst, Seoul 132714, South Korea

[3] Dongguk Univ, Div Biosci, Gyeongju 780714, South Korea

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2009年 / 47卷 / 06期

关键词：

Gardenia jasminoides Ellis; Anti-gastric activity; Genipin; Ursolic acid; Antioxidant; Anti-Helicobacter pylori; HELICOBACTER-PYLORI INFECTION; CAMPYLOBACTER; ERADICATION; SUPPRESSION; RESISTANCE;

D O I：

10.1016/j.fct.2009.01.037

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

In this study we investigated the effects of Gardenia jasminoides Ellis (GJE) extract and its constituents, such as ursolic acid and genipin, on gastritis in rats and the growth of human gastric cancer cells. The GJE extract, ursolic acid and genipin showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effects on the growth of Helicobacter pylon (H. pylori), which are almost equivalent to positive control compounds. In addition, the GJE extract and ursolic acid had cytotoxic activity against AGS and SUN638 gastric cancer cells. The genipin and ursolic acid inhibited significant HCl/ethanol-induced gastric lesions. Taken together, GJE extract and its constituents might have antigastritic activities, associated with the antioxidant activities, acid-neutralizing capacities, and anti-H. pylori action. Also, we could suggest that genipin and ursolic acid may be useful for the treatment and/or protection of gastritis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.

引用

页码：1127 / 1131

页数：5

共 26 条

[1]

Azuma T, 1998, CANCER, V82, P1013, DOI 10.1002/(SICI)1097-0142(19980315)82:6<1013::AID-CNCR2>3.0.CO

[2]

2-F

[3] In vitro anti-Helicobacter pylori activity of some flavonoids and their metabolites [J].

Bae, EA ;

Han, MJ ;

Kim, DH .

PLANTA MEDICA, 1999, 65 (05) :442-443

[4] VITAMIN-C AND CANCER PREVENTION - THE EPIDEMIOLOGIC EVIDENCE [J].

BLOCK, G .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 53 (01) :S270-S282

[5] Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein [J].

Choi, Cheol-Hee ;

Cha, Yoon-Jung ;

An, Chun-San ;

Kim, Kyung-Jong ;

Kim, Kweon-Cheon ;

Moon, Sung-Pyo ;

Lee, Zang Hee ;

Min, Young-Don .

CANCER CELL INTERNATIONAL, 2004, 4 (1)

[6] Reactive oxygen species activity and lipid peroxidation in Helicobacter pylori associated gastritis:: relation to gastric mucosal ascorbic acid concentrations and effect of H-pylori eradication [J].

Drake, IM ;

Mapstone, NP ;

Schorah, CJ ;

White, KLM ;

Chalmers, DM ;

Dixon, MF ;

Axon, ATR .

GUT, 1998, 42 (06) :768-771

[7] Antimicrobial resistance and Helicobacter pylori [J].

Goddard, AF ;

Logan, RPH .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 37 (04) :639-643

[8] Simultaneous determination of five major biologically active ingredients in different parts of Gardenia jasminoides fruits by HPLC with diode-array detection [J].

He, Mei-Lian ;

Cheng, Xiao-Wei ;

Chen, Jia-Kuan ;

Zhou, Tong-Shui .

CHROMATOGRAPHIA, 2006, 64 (11-12) :713-717

[9]

*INT AG RES CANC, 1994, MON INT AG RES CANC, V61

[10]

Lee EJ, 2005, FOOD SCI BIOTECHNOL, V14, P123

← 1 2 3 →