Forebrain pain mechanisms

被引:278
作者
Neugebauer, Volker [1 ]
Galhardo, Vasco [2 ,3 ]
Maione, Sabatino [4 ]
Mackey, Sean C. [5 ]
机构
[1] Univ Texas Med Branch, Dept Neurosci & Cell Biol, Galveston, TX 77555 USA
[2] Univ Porto, Fac Med, Inst Histol & Embriol, P-4200319 Oporto, Portugal
[3] Univ Porto, IBMC, P-4200319 Oporto, Portugal
[4] Univ Naples 2, Dept Expt Med, I-80138 Naples, Italy
[5] Stanford Univ, Sch Med, Palo Alto, CA 94304 USA
基金
美国国家卫生研究院;
关键词
Pain; Emotion; Cognition; Decision-making; Amygdala; Prefrontal cortex; VENTROMEDIAL PREFRONTAL CORTEX; CENTRAL AMYGDALA NEURONS; CHRONIC BACK-PAIN; CORTICOTROPIN-RELEASING-FACTOR; POSITRON-EMISSION-TOMOGRAPHY; PERIPHERAL-NERVE INJURY; DECISION-MAKING TASK; MAGNETIC-RESONANCE SPECTROSCOPY; SOMATIC MARKER HYPOTHESIS; MGLUR-MEDIATED INHIBITION;
D O I
10.1016/j.brainresrev.2008.12.014
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Emotional-affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain areas outside the traditional pain processing network contribute critically to emotional-affective responses and cognitive deficits related to pain. These brain areas include different nuclei of the amygdala and certain prefrontal cortical areas. Their roles in various aspects of pain will be discussed. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Supporting data from preclinical studies in neuropathic pain models will be presented. Neuroimaging analysis provides evidence for plastic changes in the pain processing brain network. Results of clinical studies in neuropathic pain patients suggest that neuroimaging may help determine mechanisms of altered brain functions in pain as well as monitor the effects of pharmacologic interventions to optimize treatment in individual patients. Recent progress in the analysis of higher brain functions emphasizes the concept of pain as a multidimensional experience and the need for integrative approaches to determine the full spectrum of harmful or protective neurobiological changes in pain. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:226 / 242
页数:17
相关论文
共 216 条
[1]   Expression of IL-1β in supraspinal brain regions in rats with neuropathic pain [J].
Apkarian, A. Vania ;
Lavarello, Simona ;
Randolf, Anke ;
Berra, Hector H. ;
Chialvo, Dante R. ;
Besedovsky, Hugo O. ;
del Rey, Adriana .
NEUROSCIENCE LETTERS, 2006, 407 (02) :176-181
[2]   Chronic pain patients are impaired on an emotional decision-making task [J].
Apkarian, AV ;
Sosa, Y ;
Krauss, BR ;
Thomas, PS ;
Fredrickson, BE ;
Levy, RE ;
Harden, RN ;
Chialvo, DR .
PAIN, 2004, 108 (1-2) :129-136
[3]   Human brain mechanisms of pain perception and regulation in health and disease [J].
Apkarian, AV ;
Bushnell, MC ;
Treede, RD ;
Zubieta, JK .
EUROPEAN JOURNAL OF PAIN, 2005, 9 (04) :463-484
[4]   Chronic back pain is associated with decreased prefrontal and thalamic gray matter density [J].
Apkarian, AV ;
Sosa, Y ;
Sonty, S ;
Levy, RM ;
Harden, RN ;
Parrish, TB ;
Gitelman, DR .
JOURNAL OF NEUROSCIENCE, 2004, 24 (46) :10410-10415
[5]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[6]   Amygdala input to medial prefrontal cortex (mPFC) in the rat: A light and electron microscope study [J].
Bacon, SJ ;
Headlam, AJN ;
Gabbott, PLA ;
Smith, AD .
BRAIN RESEARCH, 1996, 720 (1-2) :211-219
[7]   Beyond feeling: Chronic pain hurts the brain, disrupting the default-mode network dynamics [J].
Baliki, Marwan N. ;
Geha, Paul Y. ;
Apkarian, A. Vania ;
Chialvo, Dante R. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (06) :1398-1403
[8]   Chronic pain and the emotional brain: Specific brain activity associated with spontaneous fluctuations of intensity of chronic back pain [J].
Baliki, Marwan N. ;
Chialvo, Dante R. ;
Geha, Paul Y. ;
Levy, Robert M. ;
Harden, R. Norman ;
Parrish, Todd B. ;
Apkarian, A. Vania .
JOURNAL OF NEUROSCIENCE, 2006, 26 (47) :12165-12173
[9]   Reward circuitry activation by noxious thermal stimuli [J].
Becerra, L ;
Breiter, HC ;
Wise, R ;
Gonzalez, RG ;
Borsook, D .
NEURON, 2001, 32 (05) :927-946
[10]   Trigeminal neuropathic pain alters responses in CNS circuits to mechanical (brush) and thermal (cold and heat) stimuli [J].
Becerra, Lino ;
Morris, Susie ;
Bazes, Shelly ;
Gostic, Richard ;
Sherman, Seth ;
Gostic, Julie ;
Pendse, Gautam ;
Moulton, Eric ;
Scrivani, Steven ;
Keith, David ;
Chizh, Boris ;
Borsook, David .
JOURNAL OF NEUROSCIENCE, 2006, 26 (42) :10646-10657