Synthesis and Crystal Structure of (S)-N-(hexahydro-2-oxo-1H-azepin-3-yl)-3-phenyl-2-propenamide

被引：0

作者：

Li Xiao-Lin ^{[1
]}

Fang Zheng ^{[1
]}

Zhang Feng ^{[1
]}

Zeng Wen-Bo ^{[2
]}

Guo Kai ^{[2
]}

机构：

[1] Nanjing Univ Technol, Sch Pharmaceut Sci, Nanjing 211816, Jiangsu, Peoples R China

[2] Nanjing Univ Technol, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Jiangsu, Peoples R China

来源：

CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2014年 / 33卷 / 06期

关键词：

synthesis; propenamide; caprolactam; crystal structure; SPECTRUM CHEMOKINE INHIBITORS; AMINOTHIAZOLE DERIVATIVES; IN-VIVO;

D O I：

暂无

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The title compound (S)-N-(hexahydro-2-oxo-1H-azepin-3-yl)-3-phenyl-2-propenamide (C15H18N2O2, M-r= 258.31) was synthesized by the reaction of (S)-alpha-amino-epsilon-caprolactam with 3-phenyl-2- propenoyl chloride. Its chemical structure was determined by H-1 NMR, C-13 NMR, H RMS and X-ray single-crystal diffraction. The crystal belongs to the monoclinic system, space group P2(1)/n with a = 14.957(3), b = 4.884(1), c = 18.630(4) angstrom, beta = 95.91(3)degrees, V = 1353.7(5) angstrom(3), Z = 4, D-c = 1.267 g/cm(3), mu = 0.085 mm(-1), F(000) = 552, R = 0.0671 and wR = 0.1547 for 2473 observed reflections with I> 2 sigma(I).

引用

页码：851 / 854

页数：4

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