Role of CD83 in the immunomodulation of dendritic cells

被引：73

作者：

Lechmann, M ^{[1
]}

Zinser, E ^{[1
]}

Golka, A ^{[1
]}

Steinkasserer, A ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Dermatol, D-91052 Erlangen, Germany

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2002年 / 129卷 / 02期

关键词：

dendritic cells; CD83;

D O I：

10.1159/000065883

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Glycoprotein CD83 is one of the best-known maturation markers for human dendritic cells (DCs). The fact that CD83 is strongly upregulated together with co-stimulatory molecules such as CD80 and CD86 during DC maturation suggests it plays an important role in the induction of immune responses. Infection studies with herpes simplex virus type 1 (HSV-1) and the inhibition of the CD83 mRNA specific transport from the nucleus to the cytoplasm suggested a possible functional role for CD83. The first clear proof that CD83 is indeed important for DC biology came from recently performed studies using a soluble form of the extracellular CD83 domain. DC-mediated T cell proliferation could be completely inhibited using this recombinant molecule. Additional studies elucidated immunostimulatory as well as regulatory effects of the CD83 molecule. Furthermore, CD83-/- knockout mice revealed a block in CD4+ T cell generation, a new possible immunomodulatory function of CD83. Copyright (C) 2002 S. Karger AG, Basel.

引用

页码：113 / 118

页数：6

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