THE ROLE OF MAP KINASES IN IMMUNE RESPONSE

被引：0

作者：

Krzyzowska, Malgorzata ^{[1
]}

Swiatek, Weronika ^{[1
]}

Fijalkowska, Beata ^{[1
]}

Niemialtowski, Marek ^{[1
]}

Scollenberger, Ada ^{[1
]}

机构：

[1] SGGW, Wydzial Med Weterynaryjnej, Katedra Nauk Przedklin, Zaklad Imunol, PL-02786 Warsaw, Poland

来源：

POSTEPY BIOLOGII KOMORKI | 2009年 / 36卷 / 02期

关键词：

MAP kinases; ERK; JNK; p38; ACTIVATED PROTEIN-KINASE; T-CELL-ACTIVATION; SIGNALING PATHWAYS; MESSENGER-RNA; P38; MAPK; RECEPTOR; EXPRESSION; ERK; JNK; REQUIREMENT;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The MAP kinases (MAPKs), including ERK, JNK and p38 families consist the part of intracellular signaling network, which is essential for signal transduction from receptors and biological answer to the stimuli. Activity of MAPKs plays a crucial role in normal functioning of the immune system. By taking part in cytokine production upon signaling from activated TLR receptors, MAPKs are involved in initiation of innate immunity and in responses to binding of cytokines by appropriate receptors. MAPKs activity is also important for T and B lymphocyte differentiation, by the ITAM signaling pathway. Moreover, their involvement in apoptosis supports lymphocyte T cytotoxicity, and enables to remove damaged, infected or transformed cells. Correct functioning of the MAPK signaling is crucial for effective immune response, and therefore MAPKs inhibitors consist a promising therapeutic goal.

引用

页码：295 / 308

页数：14

共 68 条

[1] ERK-8, a new member of the mitogen-activated protein kinase family [J].