Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1α,25-dihydroxyvitamin D3

被引：7
|
作者：
De Buysser, Frederik [1 ]
Verlinden, Lieve [2 ]
Verstuyf, Annemieke [2 ]
De Clercq, Pierre J. [1 ]
机构：
[1] Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium
[2] Catholic Univ Louvain, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期
关键词：
Spirocyclic decanones; Calcitriol analogs; Enantioselective synthesis; VITAMIN-D; ENANTIOMERICALLY PURE; BIOLOGICAL-ACTIVITY; CATALYZED-REACTIONS;
D O I：
10.1016/j.tetlet.2009.05.005
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In search of analogs of 1 alpha,25-dihydroxyvitamin D-3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4174 / 4177
页数：4
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