Synthesis of 22-oxaspiro[4.5]decane CD-ring modified analogs of 1α,25-dihydroxyvitamin D3

被引：7

作者：

De Buysser, Frederik ^{[1
]}

Verlinden, Lieve ^{[2
]}

Verstuyf, Annemieke ^{[2
]}

De Clercq, Pierre J. ^{[1
]}

机构：

[1] Univ Ghent, Dept Organ Chem, B-9000 Ghent, Belgium

[2] Catholic Univ Louvain, Lab Expt Med & Endocrinol, B-3000 Louvain, Belgium

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 28期

关键词：

Spirocyclic decanones; Calcitriol analogs; Enantioselective synthesis; VITAMIN-D; ENANTIOMERICALLY PURE; BIOLOGICAL-ACTIVITY; CATALYZED-REACTIONS;

D O I：

10.1016/j.tetlet.2009.05.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In search of analogs of 1 alpha,25-dihydroxyvitamin D-3 featuring a dissociation of calcemic and other activities, a series of stereoisomeric 19-nor-22-oxa derivatives, characterized by a spiro[4.5]decane cyclic system instead of the classical CD-ring system, have been synthesized in an enantioselective way. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：4174 / 4177

页数：4

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